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010   $a3-319-12232-0
024 7 $a10.1007/978-3-319-12232-8
035   $a(CKB)3710000000324621
035   $a(EBL)1968676
035   $a(OCoLC)908090341
035   $a(SSID)ssj0001408214
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035   $a(PQKBTitleCode)TC0001408214
035   $a(PQKBWorkID)11347649
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035   $a(DE-He213)978-3-319-12232-8
035   $a(MiAaPQ)EBC1968676
035   $a(PPN)18315410X
035   $a(EXLCZ)993710000000324621
100   $a20141227d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aComplex Structure and Dynamics of the Heart /$fby Philip Bittihn
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015.
215   $a1 online resource (214 p.)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $aDescription based upon print version of record.
311   $a3-319-12231-2 
320   $aIncludes bibliographical references and index.
327   $aIntroduction -- Methods -- Results -- Conclusion -- Appendix A Modeling Details -- Appendix B Supplementary Data -- Appendix C MediaSim -- An Open Framework for Simulating Extended Systems -- Index.
330   $aThis award-winning thesis investigates the mechanisms underlying cardiac arrhythmia development and termination from an entirely new perspective. By viewing the heart as a complex system, the author uses theoretical tools from nonlinear dynamics combined with numerical simulations and experiments to achieve insights into the relationship between its structure and dynamics, thereby paving the way towards innovative low-energy defibrillation strategies. The work tackles, among other things: the effect of substrate heterogeneity on the spatial-temporal dynamics of cardiac arrhythmias and ways in which weak pulsed electric fields can be used to control these dynamics in heterogeneous cardiac tissue. The long-term vision of this research is to replace the current strategy of applying painful and sometimes tissue damaging electric shock ? currently the only reliable way to terminate life-threatening fibrillation ? by a more subtle but equally effective intervention. The book maps out a number of promising research directions for biophysicists and medical researchers working on the origins and treatment of cardiac arrhythmias.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aBiophysics
606   $aBiological physics
606   $aStatistical physics
606   $aCardiology
606   $aPhysics
606   $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008
606   $aApplications of Nonlinear Dynamics and Chaos Theory$3https://scigraph.springernature.com/ontologies/product-market-codes/P33020
606   $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037
606   $aNumerical and Computational Physics, Simulation$3https://scigraph.springernature.com/ontologies/product-market-codes/P19021
615  0$aBiophysics.
615  0$aBiological physics.
615  0$aStatistical physics.
615  0$aCardiology.
615  0$aPhysics.
615 14$aBiological and Medical Physics, Biophysics.
615 24$aApplications of Nonlinear Dynamics and Chaos Theory.
615 24$aCardiology.
615 24$aNumerical and Computational Physics, Simulation.
676   $a530
676   $a530.1
676   $a571.4
676   $a616.12
700   $aBittihn$b Philip$4aut$4http://id.loc.gov/vocabulary/relators/aut$0792257
906   $aBOOK
912   $a9910300407303321
996   $aComplex Structure and Dynamics of the Heart$91771523
997   $aUNINA