LEADER 05559nam 22008055 450 001 9910300382803321 005 20200630020128.0 010 $a3-642-53839-8 024 7 $a10.1007/978-3-642-53839-1 035 $a(CKB)3710000000093974 035 $a(EBL)1698375 035 $a(OCoLC)881161888 035 $a(SSID)ssj0001187349 035 $a(PQKBManifestationID)11754685 035 $a(PQKBTitleCode)TC0001187349 035 $a(PQKBWorkID)11256987 035 $a(PQKB)10104902 035 $a(MiAaPQ)EBC1698375 035 $a(DE-He213)978-3-642-53839-1 035 $a(PPN)177825316 035 $a(EXLCZ)993710000000093974 100 $a20140313d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMembrane Transport Mechanism$b[electronic resource] $e3D Structure and Beyond /$fedited by Reinhard Krämer, Christine Ziegler 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (282 p.) 225 1 $aSpringer Series in Biophysics,$x0932-2353 ;$v17 300 $aDescription based upon print version of record. 311 $a3-642-53838-X 320 $aIncludes bibliographical references at the end of each chapters. 327 $aDance Lessons for Proteins: The Dynamics and Thermodynamics of a Sodium/Aspartate Symporter -- Characterizing the Structure, Function and Evolution of Human Solute Carrier (SLC) Transporters Using Computational Approaches -- Structures of the Prokaryotic Galactose Transporter vSGLT and Their Implications on Alternating Access Mechanism in Human SGLT1 -- Moving Crystallographic Snapshots: A Mechanism for Transport Regulation in BetP -- Development of Refined Homology Models: Adding the Missing Information to the Medically Relevant Neurotransmitter Transporters -- The Life and Times of Lac Permease: Crystals Ain?t Enough -- Alternating Access Within the POT Family of Oligopeptide -- Proton Symporters -- The Maltose ABC Transporter: Where Structure Meets Function -- Cooperative Transport Mechanism and Proton-Coupling in the Multidrug Efflux Transporter Complex ArcAB-TolC -- What Can a Living Fossil Tell Us About Evolution and Mechanism of Ion-Coupled Transporters: The Story of Small Multidrug Transporters Symmetrically Asymmetric: EmrE Seen from the NMR Perspective. 330 $aThis book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing number of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights.   The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism.   This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers.   The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture, or, more precisely, ?a molecular movie?. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics. 410 0$aSpringer Series in Biophysics,$x0932-2353 ;$v17 606 $aCell membranes  606 $aProteins  606 $aBiophysics 606 $aBiological physics 606 $aCrystallography 606 $aBioinformatics 606 $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 606 $aCrystallography and Scattering Methods$3https://scigraph.springernature.com/ontologies/product-market-codes/P25056 606 $aComputational Biology/Bioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/I23050 615 0$aCell membranes . 615 0$aProteins . 615 0$aBiophysics. 615 0$aBiological physics. 615 0$aCrystallography. 615 0$aBioinformatics. 615 14$aMembrane Biology. 615 24$aProtein Structure. 615 24$aBiological and Medical Physics, Biophysics. 615 24$aCrystallography and Scattering Methods. 615 24$aComputational Biology/Bioinformatics. 676 $a571.64 702 $aKrämer$b Reinhard$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aZiegler$b Christine$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910300382803321 996 $aMembrane Transport Mechanism$91770885 997 $aUNINA