LEADER 04700nam 22006855 450 001 9910300347903321 005 20200702133712.0 010 $a1-4939-1176-7 024 7 $a10.1007/978-1-4939-1176-9 035 $a(CKB)3710000000224473 035 $a(EBL)1802705 035 $a(SSID)ssj0001338773 035 $a(PQKBManifestationID)11704402 035 $a(PQKBTitleCode)TC0001338773 035 $a(PQKBWorkID)11345304 035 $a(PQKB)11222333 035 $a(MiAaPQ)EBC1802705 035 $a(DE-He213)978-1-4939-1176-9 035 $a(PPN)180627953 035 $a(EXLCZ)993710000000224473 100 $a20140820d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aManagement of Castration Resistant Prostate Cancer /$fedited by Fred Saad, Mario A. Eisenberger 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Humana,$d2014. 215 $a1 online resource (336 p.) 225 1 $aCurrent Clinical Urology,$x2197-7194 300 $aDescription based upon print version of record. 311 $a1-322-13329-8 311 $a1-4939-1175-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction - Castration Resistant Prostate Cancer: A Rapidly Expanding Clinical State and a Model for New Therapeutic Opportunities -- Evolution of Clinical States and the Castration Resistant Clinical Paradigm -- Molecular Mechanisms of Prostate Cancer Progression after Castration -- New Imaging Modalities -- Androgen Receptor Biology in Castration Resistant Prostate Cancer -- The Androgen Receptor as a Therapeutic Target for Castration-Resistant Prostate Cancer -- Approaches Targeting Androgen Synthesis (CYP 17 inhibitors) -- Cytotoxic Chemotherapy (Taxanes and Taxane Combinations) -- The Emerging Role of Immunotherapy in Castrate Resistant Prostate Cancer -- Bone Targeted Therapy: Rationale and Current Status -- Radium-223 and Other Radiopharmaceuticals in Prostate Cancer -- Introduction -- Phase I/II targeted treatments -- Defining Clinical Endpoints in Castration-resistant Prostate Cancer -- Angiogenesis Inhibition in Castration Resistant Prostate Cancer -- Co-targeting Adaptive Survival Pathways -- Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer -- PARP Inhibitors -- Targeting C-Met/VEGF in Castration Resistant Prostate Cancer -- Epigenetics in Castration Resistant Prostate Cancer -- Undifferentiated Prostate Cancer and the Neuroendocrine Phenotype -- Strategies Addressing Quality of Life: Patient Reported Outcome and Symptoms Management -- Evidence-Based Therapeutic Approaches for mCRPC patients: Rational Sequence of Standard Treatment Options and Design for Future Drug Development. 330 $aThis volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence-based medicine. As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy. 410 0$aCurrent Clinical Urology,$x2197-7194 606 $aUrology 606 $aOncology   606 $aInterventional radiology  606 $aUrology$3https://scigraph.springernature.com/ontologies/product-market-codes/H62002 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aInterventional Radiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H29021 615 0$aUrology. 615 0$aOncology  . 615 0$aInterventional radiology . 615 14$aUrology. 615 24$aOncology. 615 24$aInterventional Radiology. 676 $a616.9946306 702 $aSaad$b Fred$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aEisenberger$b Mario A$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910300347903321 996 $aManagement of Castration Resistant Prostate Cancer$91521889 997 $aUNINA