LEADER 05520nam 22007335 450 001 9910300342503321 005 20200630064708.0 010 $a4-431-54862-9 024 7 $a10.1007/978-4-431-54862-1 035 $a(CKB)3710000000218733 035 $a(EBL)1802975 035 $a(SSID)ssj0001338837 035 $a(PQKBManifestationID)11734515 035 $a(PQKBTitleCode)TC0001338837 035 $a(PQKBWorkID)11344692 035 $a(PQKB)11409032 035 $a(MiAaPQ)EBC1802975 035 $a(DE-He213)978-4-431-54862-1 035 $a(PPN)180621343 035 $a(EXLCZ)993710000000218733 100 $a20140805d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRegenerative Medicine for the Inner Ear$b[electronic resource] /$fedited by Juichi Ito 205 $a1st ed. 2014. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2014. 215 $a1 online resource (311 p.) 300 $aDescription based upon print version of record. 311 $a1-322-17354-0 311 $a4-431-54861-0 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPart I Targets of Regenerative Medicine for the Inner Ear -- 1 Anatomy of the Inner Ear -- 2 Therapeutic Targets and Possible Strategies for Regenerative Medicine for the Inner Ear -- 3 Hair cell -- 4 Stereocilia -- 5 Cochlear Lateral Wall -- 6 Spiral Ganglion Cell and Auditory Neuron -- 7 Synaptic Contacts between Hair Cells and Primary Neurons -- 8 Otolith -- 9 Tectorial membrane -- Part II Development of the Inner Ear -- 10 Development and regeneration -- 11 Otic Induction -- 12 Cochlear Development -- 13 Vestibular Development -- Part III Cochlear Implants -- 14 Cochlear Implant: Past, Present and Future.- 15 Recent Progress in Cochlear Implant -- 16 Regenerative medicine in cochlear implantation -- 17 Artificial cochlear epithelium -- 18 Auditory Brainstem Implant -- Part IV Hair Cell Regeneration -- 19 Hair Cell Regeneration in the Avian -- 20 Self Repair -- 21 Transdifferentiation -- 22 Dedifferentiation?mediated Regeneration -- 23 Gene Therapy -- 24 Cell Therapy -- Part V Spiral Ganglion Neuron Regeneration -- 25 Clinical Background -- 26 SGN development -- 27 Gene Therapy for Regeneration and Preservation of Spinal Ganglion Neurons -- 28 Cell therapy -- 29 Afferent dendrite and axon -- Part VI Stem Cells -- 30 Inner ear stem cells -- 31 Pluripotent Stem Cells -- 32 Somatic Stem Cells -- Part VII Future Perspective -- 33 Regenerative Medicine for the Inner Ear ? Summary. 330 $aThe research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness?vertigo, and Ménière?s disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases. 606 $aOtorhinolaryngology 606 $aRegenerative medicine 606 $aTissue engineering 606 $aOtolaryngologic surgery 606 $aGene therapy 606 $aNeurosciences 606 $aOtorhinolaryngology$3https://scigraph.springernature.com/ontologies/product-market-codes/H46007 606 $aRegenerative Medicine/Tissue Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/L16080 606 $aHead and Neck Surgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H46015 606 $aGene Therapy$3https://scigraph.springernature.com/ontologies/product-market-codes/B12020 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aOtorhinolaryngology. 615 0$aRegenerative medicine. 615 0$aTissue engineering. 615 0$aOtolaryngologic surgery. 615 0$aGene therapy. 615 0$aNeurosciences. 615 14$aOtorhinolaryngology. 615 24$aRegenerative Medicine/Tissue Engineering. 615 24$aHead and Neck Surgery. 615 24$aGene Therapy. 615 24$aNeurosciences. 676 $a617.882 702 $aIto$b Juichi$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300342503321 996 $aRegenerative Medicine for the Inner Ear$91522220 997 $aUNINA