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035   $a(DE-He213)978-1-4939-0829-5
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100   $a20140726d2014      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aMitochondrial Function in Lung Health and Disease$b[electronic resource] /$fedited by Viswanathan Natarajan, Narasimham L. Parinandi
205   $a1st ed. 2014.
210  1$aNew York, NY :$cSpringer New York :$cImprint: Humana,$d2014.
215   $a1 online resource (230 p.)
225 1 $aRespiratory Medicine,$x2197-7372
300   $aDescription based upon print version of record.
311   $a1-322-13297-6 
311   $a1-4939-0828-6 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aRole of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases -- Regulation of Mitochondrial Functions by Transcription Factor NRF2 -- Mitochondrion: A Missing Link in Asthma Pathogenesis -- ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea -- Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle -- Mitochondrial Lipid Peroxidation in Lung Damage and Disease -- The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung -- Mitochondrial Function in Lung Health and Disease -- Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial Damage.
330   $aMitochondria, often referred to as the ?powerhouses? of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis.  Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction.  Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling.  Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.  .
410  0$aRespiratory Medicine,$x2197-7372
606   $aRespiratory organs?Diseases
606   $aInternal medicine
606   $aMedicine
606   $aPneumology/Respiratory System$3https://scigraph.springernature.com/ontologies/product-market-codes/H33134
606   $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002
606   $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X
615  0$aRespiratory organs?Diseases.
615  0$aInternal medicine.
615  0$aMedicine.
615 14$aPneumology/Respiratory System.
615 24$aInternal Medicine.
615 24$aBiomedicine, general.
676   $a616.2
702   $aNatarajan$b Viswanathan$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aParinandi$b Narasimham L$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910300339703321
996   $aMitochondrial Function in Lung Health and Disease$91522147
997   $aUNINA