LEADER 05148nam 22006135 450 001 9910300333603321 005 20200701173037.0 010 $a3-7091-1535-3 024 7 $a10.1007/978-3-7091-1535-0 035 $a(CKB)2670000000423546 035 $a(EBL)1474367 035 $a(SSID)ssj0001010552 035 $a(PQKBManifestationID)11584842 035 $a(PQKBTitleCode)TC0001010552 035 $a(PQKBWorkID)11003476 035 $a(PQKB)10082251 035 $a(MiAaPQ)EBC1474367 035 $a(DE-He213)978-3-7091-1535-0 035 $a(PPN)172431816 035 $a(EXLCZ)992670000000423546 100 $a20130902d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Intervertebral Disc $eMolecular and Structural Studies of the Disc in Health and Disease /$fedited by Irving M. Shapiro, Makarand V. Risbud 205 $a1st ed. 2014. 210 1$aVienna :$cSpringer Vienna :$cImprint: Springer,$d2014. 215 $a1 online resource (440 p.) 300 $aDescription based upon print version of record. 311 $a3-7091-1534-5 320 $aIncludes bibliographical references and index. 327 $aBiomechanical and Molecular Studies of the Intervertebral Disc: Introduction to the Structure, Function and Comparative Anatomy of the Vertebrae and the Intervertebral Disc -- The Intervertebral Disc: Overview of Disc Mechanics -- Development of the Intervertebral Disc -- Proteoglycans of the Intervertebral Disc -- Collagen and Other Proteins of the Nucleus Pulposus, Annulus Fibrosus and Cartilage Endplates -- Microenvironmental Regulation of Cell Function and Extracellular Matrix Synthesis by Disc Cells -- The Effects of Mechanical Forces on Nucleus and Annulus Cells -- The Role of the ADAMTS Proteins in the Intervertebral Disc -- Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities: Epidemiology of Lumbar Disc Degeneration -- Genetic Basis of Intervertebral Disc Degeneration -- Pathogenesis of Intervertebral Disc Degeneration -- Imaging Modalities for Studying Disc Pathology -- Surgical Indications for Lumbar Degenerative Disease -- Spinal Motion Restoration Devices for the Degenerate Disc -- The Non-Surgical Treatment of Back Pain -- Back Pain and Disc Degeneration: Are They Linked?- Clinical Features and Pathobiology of Chordoma -- Models of Disc Disease and Biological Regeneration: Large Animal Models of Disc Degeneration -- Intervertebral Disc Herniation -- The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Generation -- Use of Knockout and Transgenic Mouse Models in Disc Research -- Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair -- Use of Stem Cells to Regenerate the Disc -- Gene Therapy Approaches for Disc Regeneration -- Enhancing Disc Repair by Growth Factors and Other Modalities -- Tissue Engineering of the Disc. 330 $aThe intervertebral disc is composed of a complex tissue that separates neighboring vertebrae, permits a wide range of motion, and cushions the high biomechanical forces on the spine. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, this is the only book in the past fifty years devoted entirely to the study of the intervertebral disc. The first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies for mitigating the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is dedicated to approaches that model normal development, and the elucidation of the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques.  This unique and authoritative book bridges the gap between the basic and clinical sciences; its target audience includes basic scientists, orthopedists, neurologists, rehabilitation and physical therapists, primary care physicians and chiropractors, while it also addresses the needs of graduate students, medical students, interns, fellows, and patients who suffer from disc-related pathologies. 606 $aOrthopedics 606 $aNeurosurgery 606 $aSurgical Orthopedics$3https://scigraph.springernature.com/ontologies/product-market-codes/H45027 606 $aNeurosurgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H39000 606 $aOrthopedics$3https://scigraph.springernature.com/ontologies/product-market-codes/H45000 615 0$aOrthopedics. 615 0$aNeurosurgery. 615 14$aSurgical Orthopedics. 615 24$aNeurosurgery. 615 24$aOrthopedics. 676 $a617.5 676 $a617.5/6 676 $a617.56 702 $aShapiro$b Irving M$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRisbud$b Makarand V$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300333603321 996 $aThe Intervertebral Disc$92505590 997 $aUNINA LEADER 02246nam 22004453a 450 001 9910283537003321 005 20250513221730.0 035 $a(CKB)4100000005959408 035 $a(ScCtBLL)c4abecf4-08de-4542-b64c-0b899ab533f6 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/39365 035 $a(Perlego)2328371 035 $a(EXLCZ)994100000005959408 100 $a20211214i20182019 uu 101 0 $ager 135 $auru|||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aKäthe Schirmacher $eAgitation und autobiografische Praxis zwischen radikaler Frauenbewegung und völkischer Politik /$fJohanna Gehmacher, Elisa Heinrich, Corinna Oesch 210 $cBöhlau$d2018 210 1$a[s.l.] :$cBo?hlau,$d2018. 215 $a1 online resource (598 p.) 311 08$a9783205207214 311 08$a3205207211 311 08$a9783205208280 311 08$a3205208285 330 $aDie Journalistin, Schriftstellerin und Vortragsreisende Ka?the Schirmacher (1865-1930) wird in diesem Band als eine exemplarische Protagonistin des U?bergangs europa?ischer Gesellschaften um 1900 vorgestellt. Die transnationale Agitatorin, die sich als ,moderne Frau' positionierte und in intimen Beziehungen mit Frauen lebte, adressierte als radikale Frauenrechtlerin und spa?tere vo?lkische Politikerin unterschiedliche politische Arenen. Mit ihrer Inanspruchnahme von Autorita?t und Kompetenz forderte sie die Zugangsregeln zu hegemonialen O?ffentlichkeiten heraus. In ihrem umfangreichen Nachlass wird sie als eine Erza?hlerin des eigenen Lebens sichtbar, die sich in wechselnden Konstellationen immer wieder autobiografisch neu entwarf. Mit der innovativen Konzeption einer Biografie in Koproduktion regt der Band zur methodischen Weiterentwicklung offener biografischer Forschungsprozesse an. 606 $aHistory$2bisacsh 606 $aHistory 615 7$aHistory 615 0$aHistory. 700 $aGehmacher$b Johanna$01070724 702 $aHeinrich$b Elisa 702 $aOesch$b Corinna 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910283537003321 996 $aKa?the Schirmacher$92564856 997 $aUNINA