LEADER 01036cam a2200265 i 4500 001 991004125709707536 008 090202c2003 xxu 00 eng d 020 $a0387951709 035 $ab13806816-39ule_inst 040 $aSet. Economia - SEMS$bita 082 $a519.232 100 1 $aFan, Jianqing$0280564 245 10$aNonlinear time series :$bnonparametric and parametric methods /$cJianqing Fan, Qiwei Yao 260 $aNew York [etc.] :$bSpringer,$cc2003 300 $axix, 551 p. ;$c25 cm 440 0$aSpringer series in statistics 504 $aBibliografia: p. 487-536 650 04$aSerie temporali$xAnalisi non lineare 700 1 $aYao, Qiwei$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0280565 907 $a.b13806816$b28-01-14$c02-02-09 912 $a991004125709707536 945 $aLE025 ECO 519.2 FAN01.01$g1$i2025000112230$lle025$o-$pE0.00$q-$rl$s- $t0$u6$v5$w6$x0$y.i14924729$z02-02-09 996 $aNonlinear time series$9672370 997 $aUNISALENTO 998 $ale025$b02-02-09$cm$da $e-$feng$gxxu$h0$i0 LEADER 04933nam 22006615 450 001 9910300327503321 005 20200702172233.0 010 $a3-642-54066-X 024 7 $a10.1007/978-3-642-54066-0 035 $a(CKB)3710000000106777 035 $a(EBL)1731244 035 $a(OCoLC)883570906 035 $a(SSID)ssj0001204983 035 $a(PQKBManifestationID)11788707 035 $a(PQKBTitleCode)TC0001204983 035 $a(PQKBWorkID)11180627 035 $a(PQKB)11035743 035 $a(MiAaPQ)EBC1731244 035 $a(DE-He213)978-3-642-54066-0 035 $a(PPN)178317098 035 $a(EXLCZ)993710000000106777 100 $a20140430d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular Diagnostics for Dermatology $ePractical Applications of Molecular Testing for the Diagnosis and Management of the Dermatology Patient /$fby Gregory A. Hosler, Kathleen M. Murphy 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (370 p.) 300 $aDescription based upon print version of record. 311 $a3-642-54065-1 320 $aIncludes bibliographical references. 327 $aIntroduction -- Terms and Definitions -- Basics of Molecular Biology and Nucleic Acids -- Principles of the Molecular Basis for Disease -- Molecular Testing Methods -- PCR and PCR-based Assays -- In situ Hybridization -- FISH and Cytogenetics -- Comparative Genomic Hybridization -- Microarray Analysis -- Melanoma -- Cutaneous Lymphoma and Leukemia Cutis -- Soft Tissue tumors -- Genodermatoses -- Infectious Disease -- Viral -- Bacterial and Mycobacterial -- Fungi and Parasites -- Emerging Molecular Applications in Dermatology -- Pharmacogenetics/Pharmacogenomics -- Theranostics. 330 $aThis textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers ? clinicians, pathologists, laboratorians, and other inquisitive minds ? independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing ?excise and pray? approaches with personalized medicine. 606 $aDermatology 606 $aPathology 606 $aDiagnosis, Laboratory 606 $aDermatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H1900X 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 606 $aLaboratory Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B15007 615 0$aDermatology. 615 0$aPathology. 615 0$aDiagnosis, Laboratory. 615 14$aDermatology. 615 24$aPathology. 615 24$aLaboratory Medicine. 676 $a610 676 $a610724 676 $a616.07 676 $a616.5 700 $aHosler$b Gregory A$4aut$4http://id.loc.gov/vocabulary/relators/aut$0755402 702 $aMurphy$b Kathleen M$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910300327503321 996 $aMolecular Diagnostics for Dermatology$92544363 997 $aUNINA