LEADER 04218nam 22005895 450 001 9910300313203321 005 20200701215025.0 010 $a3-319-64451-3 024 7 $a10.1007/978-3-319-64451-6 035 $a(CKB)4100000000882252 035 $a(DE-He213)978-3-319-64451-6 035 $a(MiAaPQ)EBC5092597 035 $a(PPN)220126070 035 $a(EXLCZ)994100000000882252 100 $a20171006d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aD-type Cyclins and Cancer$b[electronic resource] /$fedited by Philip W. Hinds, Nelson E. Brown 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2018. 215 $a1 online resource (IX, 152 p. 29 illus., 25 illus. in color.) 225 1 $aCurrent Cancer Research,$x2199-2584 311 $a3-319-64449-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aThe D-type Cyclins: A Historical Perspective -- Mammalian Development and Cancer ? A Brief History of Mice Lacking D-type Cyclins or Cdk4/6 -- D-type Cyclins and Gene Transcription -- Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis -- Cyclin D1, Metabolism, and the Autophagy-Senescence Balance -- Shifting a Paradigm: Cyclin D Activates pRb by Mono-Phosphorylation. 330 $aThis volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the ?retinoblastoma pathway? to incorporate new evidence that suggests that cyclin D1?s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases. 410 0$aCurrent Cancer Research,$x2199-2584 606 $aCancer research 606 $aCell cycle 606 $aMolecular biology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aCancer research. 615 0$aCell cycle. 615 0$aMolecular biology. 615 14$aCancer Research. 615 24$aCell Cycle Analysis. 615 24$aMolecular Medicine. 676 $a616.994071 702 $aHinds$b Philip W$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBrown$b Nelson E$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910300313203321 996 $aD-type Cyclins and Cancer$91745065 997 $aUNINA