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024 7 $a10.1007/978-3-319-63187-5
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100   $a20171124d2018      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aChromatin Regulation of Early Embryonic Lineage Specification /$fedited by Jason Knott, Keith Latham
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (VII, 78 p. 16 illus. in color.) 
225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x0301-5556 ;$v229
311   $a3-319-63186-1 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aCHD1 controls cell lineage specification through zygotic genome activation -- Chromatin remodelling proteins and cell fate decisions in mammalian preimplantation development -- Transcriptional regulation and genes involved in first lineage specification during preimplantation development -- ROCK and RHO playlist for preimplantation development: Streaming to HIPPO pathway and apicobasal polarity in the first cell differentiation -- XEN and the art of stem cell maintenance - molecular mechanisms maintaining cell fate and self-renewal in extraembryonic endoderm stem (XEN) cell lines.  .
330   $aFive leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages. .
410  0$aAdvances in Anatomy, Embryology and Cell Biology,$x0301-5556 ;$v229
606   $aHuman genetics
606   $aCytology
606   $aHuman physiology
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
615  0$aHuman genetics.
615  0$aCytology.
615  0$aHuman physiology.
615 14$aHuman Genetics.
615 24$aCell Biology.
615 24$aHuman Physiology.
676   $a611.01816
676   $a599.935
702   $aKnott$b Jason$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aLatham$b Keith$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910300308403321
996   $aChromatin Regulation of Early Embryonic Lineage Specification$91743097
997   $aUNINA