LEADER 03321nam  22004695  450 
001 9910300293103321
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010   $a3-319-40522-5
024 7 $a10.1007/978-3-319-40522-3
035   $a(CKB)4100000002485274
035   $a(MiAaPQ)EBC5310065
035   $a(DE-He213)978-3-319-40522-3
035   $a(PPN)224639706
035   $a(EXLCZ)994100000002485274
100   $a20180222d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $2rdacontent
182   $2rdamedia
183   $2rdacarrier
200 10$aObesity, Type 2 Diabetes and the Adipose Organ $eA Pictorial Atlas from Research to Clinical Applications /$fby Saverio Cinti
205   $a2nd ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (453 pages) $cillustrations
311   $a3-319-40520-9 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aThe Adipose Organ -- Brown Adipose Tissue (BAT) -- White Adipose Tissue (WAT) -- The Adipose Organ: Cold Acclimation -- BAT -- WAT -- The Adipose Organ: Warm Acclimation: BAT -- The Obese Adipose Organ: BAT -- The Fasted Adipose Organ: WAT -- BAT -- The Adipose Organ During Lactation: WAT -- BAT -- The Fetal Adipose Organ -- The Adipose Organ In Genetically Modified Models.  .
330   $aThis richly illustrated book provides a detailed description of the gross anatomy, light microscopy, immunohistochemistry, and electron microscopy of the adipose organ, which comprises subcutaneous and visceral fat depots. Findings in mice of differing genetic backgrounds (obesity prone and resistant) and maintained in standard and various physiologic and pathologic conditions are presented. The latter conditions include chronic cold exposure, warm exposure, fasting, pregnancy?lactation, and obesity. Features of the fetal adipose organ are described in a separate chapter, and results from transgenic mice are also presented when relevant. The human adipose organ is addressed in several chapters that include magnetic resonance and fetal findings. Most of the results regarding the adipose organ anatomy in different physiologic conditions are new, and the story of pink adipocytes (white-to-pink transdifferentiation) is quite innovative. The concept of using browning of the adipose organ as a therapeutic tool for obesity must take into consideration the anatomic and morphologic aspects described here, and the study of pink adipocytes could lead to a better comprehension of breast cancer tumor biology. This book will be of interest to all scientists who deal with obesity and related disorders.
606   $aDiabetes
606   $aEndocrinology
606   $aDiabetes$3https://scigraph.springernature.com/ontologies/product-market-codes/H33045
606   $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053
615  0$aDiabetes.
615  0$aEndocrinology.
615 14$aDiabetes.
615 24$aEndocrinology.
676   $a611.01827
700   $aCinti$b Saverio$4aut$4http://id.loc.gov/vocabulary/relators/aut$0749197
906   $aBOOK
912   $a9910300293103321
996   $aObesity, Type 2 Diabetes and the Adipose Organ$91751222
997   $aUNINA