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010   $a3-319-94571-8
024 7 $a10.1007/978-3-319-94571-2
035   $a(CKB)4100000006674610
035   $a(MiAaPQ)EBC5528140
035   $a(DE-He213)978-3-319-94571-2
035   $a(PPN)230542042
035   $a(EXLCZ)994100000006674610
100   $a20180926d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAlagille Syndrome $ePathogenesis and Clinical Management  /$fedited by Binita M. Kamath, Kathleen M. Loomes
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (205 pages)
311   $a3-319-94570-X 
327   $aThe Alagille Syndrome: Overview and Introduction -- Bile Duct Development and the Notch Signaling Pathway -- Genetics of Alagille Syndrome -- Liver Disease in Alagille Syndrome -- Transplant Considerations in Alagille Syndrome -- Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome -- Vascular Manifestations in Alagille Syndrome -- The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development -- Skeletal Involvement in Alagille Syndrome -- Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving Phenotype -- Health-Related Quality of Life and Neurocognition in Alagille Syndrome -- Future Therapeutic Approaches for Alagille Syndrome.
330   $aThis text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options. Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts. .
606   $aGastroenterology 
606   $aHepatology
606   $aCardiology
606   $aGastroenterology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33061
606   $aHepatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33088
606   $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037
615  0$aGastroenterology .
615  0$aHepatology.
615  0$aCardiology.
615 14$aGastroenterology.
615 24$aHepatology.
615 24$aCardiology.
676   $a616.042
702   $aKamath$b Binita M$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aLoomes$b Kathleen M$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910300262603321
996   $aAlagille Syndrome$91742375
997   $aUNINA