LEADER 03981nam 22006855 450 001 9910300237603321 005 20250710080229.0 010 $a1-4939-2047-2 024 7 $a10.1007/978-1-4939-2047-1 035 $a(CKB)3710000000375207 035 $a(EBL)1997938 035 $a(SSID)ssj0001465749 035 $a(PQKBManifestationID)11917435 035 $a(PQKBTitleCode)TC0001465749 035 $a(PQKBWorkID)11478348 035 $a(PQKB)11594980 035 $a(DE-He213)978-1-4939-2047-1 035 $a(MiAaPQ)EBC1997938 035 $a(PPN)184896231 035 $a(EXLCZ)993710000000375207 100 $a20150311d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTargeted Therapies for Solid Tumors $eA Handbook for Moving Toward New Frontiers in Cancer Treatment /$fedited by Antonio Russo, Rafael Rosell, Christian Rolfo 205 $a1st ed. 2015. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Humana,$d2015. 215 $a1 online resource (270 p.) 225 1 $aCurrent Clinical Pathology,$x2197-7828 300 $aDescription based upon print version of record. 311 08$a1-4939-2046-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction -- Oncogene Addiction in Solid Tumors -- Pharmacology and Clinical Development of New Molecularly Targeted Agents -- Biomarkers as Prognostic, Predictive and Surrogate Endpoints -- Evaluation of Response in Malignant Tumors Treated with Targeted Agents -- Targeted Therapies for HER2-Positive Breast Cancer -- Role of PARP Inhibitors in Triple Negative Breast Cancer (TNBC) -- Targeted Therapies in Squamous Cell Carcinoma of the Head and Neck -- Targeted Therapies for NSCLC -- Targeted Therapies for Gastric Cancer -- Targeted Therapies for Pancreatic Cancer -- Targeted Therapies in Hepatocellular Carcinoma -- Targeted Therapies for Colorectal Cancer -- Targeted Therapy in Gastrointestinal Stromal Tumors -- Targeted Therapies in Kidney Cancer -- Targeted Therapies in Melanoma -- Targeted Therapies for Prostate Cancer -- Targeted Therapies for Bone Metastases. 330 $aThis volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice. 410 0$aCurrent Clinical Pathology,$x2197-7828 606 $aPathology 606 $aOncology 606 $aCancer 606 $aPathology 606 $aOncology 606 $aCancer Biology 615 0$aPathology. 615 0$aOncology. 615 0$aCancer. 615 14$aPathology. 615 24$aOncology. 615 24$aCancer Biology. 676 $a616.992 702 $aRusso$b Antonio$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRosell$b Rafael$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRolfo$b Christian$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910300237603321 996 $aTargeted Therapies for Solid Tumors$91821468 997 $aUNINA