LEADER 05022nam 22007695 450 001 9910300236103321 005 20200702130359.0 010 $a3-319-17903-9 024 7 $a10.1007/978-3-319-17903-2 035 $a(CKB)3710000000434077 035 $a(EBL)2094784 035 $a(SSID)ssj0001524966 035 $a(PQKBManifestationID)11869184 035 $a(PQKBTitleCode)TC0001524966 035 $a(PQKBWorkID)11485609 035 $a(PQKB)10360276 035 $a(DE-He213)978-3-319-17903-2 035 $a(MiAaPQ)EBC2094784 035 $a(PPN)186395973 035 $a(EXLCZ)993710000000434077 100 $a20150610d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aKidney Cancer $ePrinciples and Practice /$fedited by Primo N. Lara, Eric Jonasch 205 $a2nd ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (400 p.) 300 $aDescription based upon print version of record. 311 $a3-319-17902-0 320 $aIncludes bibliographical references. 327 $aPart 1: Epidemiology and Biology Epidemiology of Kidney Cancer -- Pathological Classification -- Molecular Biology of Kidney Cancer --  Biomarkers for Kidney Cancer -- Genetic Heterogeneity of Kidney Cancer -- Metabolic Basis of Kidney Cancer. Part 2: Clinical Considerations Clinical Presentation and Staging.-  Hereditary Kidney Cancer.  Part 3: Surgical and Local Control Modalities Surgical Approaches to Early Stage Kidney Cancer -- Cytoreductive Nephrectomy -- Metastasectomy -- Energy Ablative Techniques in Kidney Cancer -- The Role of Radiation Therapy in Kidney Cancer. Part 4: Systemic Therapy Considerations Adjuvant Systemic Therapy -- Cytokines and Vaccine Therapy -- PD1 and PDL1 Targeted Therapy -- Angiogenesis Inhibitor Therapy -- The Role of mTOR inhibitors and PI3K Pathway Blockade -- Sequential versus Combination Strategies -- Presurgical Therapy in Kidney Cancer -- Toxicity Management for Patients on Targeted Therapies -- Emerging Agents in Kidney Cancer. 330 $aKidney Cancer: Principles and Practice is a comprehensive and interdisciplinary textbook that encompasses all clinically relevant aspects of the disease. This new edition has been extensively updated and includes brand new material covering the most recent developments in kidney cancer diagnosis and therapy. The user-friendly and clinically oriented content of the book guarantees that it will be of great interest to a wide range of medical professionals, and every effort has been made to ensure that contributions are both easy to understand and directly related to patient care. Content presentation departs from the usual dense chapter format featuring a lengthy series of paragraphs. Instead, each chapter contains several boxed sections, including one that summarizes essential "take home points" for the busy clinician and another that presents a patient-oriented case highlighting the clinical application of elements discussed in that chapter. In addition, accessible original images, illustrations, and diagrams (some in full color) are used to simplify particularly complex material. This book will be of value for clinicians, researchers, residents, fellows, students, and knowledgeable lay people. The contributors comprise an international group of authors with expertise in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others.  . 606 $aOncology   606 $aSurgery 606 $aCancer research 606 $aInternal medicine 606 $aPathology 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aSurgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H59001 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 615 0$aOncology  . 615 0$aSurgery. 615 0$aCancer research. 615 0$aInternal medicine. 615 0$aPathology. 615 14$aOncology. 615 24$aSurgery. 615 24$aCancer Research. 615 24$aInternal Medicine. 615 24$aPathology. 676 $a610 676 $a614.5999 676 $a616 676 $a616.07 676 $a616994 676 $a617 702 $aLara$b Primo N$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aJonasch$b Eric$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300236103321 996 $aKidney cancer$92027966 997 $aUNINA