LEADER 04628nam 22007575 450 001 9910300218503321 005 20250609110112.0 010 $a3-319-15621-7 024 7 $a10.1007/978-3-319-15621-7 035 $a(CKB)3710000000399938 035 $a(EBL)2096101 035 $a(SSID)ssj0001501654 035 $a(PQKBManifestationID)11968035 035 $a(PQKBTitleCode)TC0001501654 035 $a(PQKBWorkID)11457051 035 $a(PQKB)11474763 035 $a(DE-He213)978-3-319-15621-7 035 $a(MiAaPQ)EBC2096101 035 $a(PPN)185488587 035 $a(MiAaPQ)EBC3109757 035 $a(iGPub)SPNA0037295 035 $a(EXLCZ)993710000000399938 100 $a20150414d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPathophysiology of Headaches $eFrom Molecule to Man /$fedited by Messoud Ashina, Pierangelo Geppetti 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (277 p.) 225 1 $aHeadache,$x2197-652X 300 $aDescription based upon print version of record. 311 08$a3-319-15620-9 320 $aIncludes bibliographical references and index. 327 $a1 Anatomy of headache -- 2 Animal models of migraine -- 3 Animal models of other primary headaches -- 4 Genetics of headache -- 5 Human models of primary headaches -- 6 Imaging of migraine -- 7 Imaging of other primary headaches -- 8 Neurophysiology of migraine -- 9 Neurophysiology of other primary headaches -- 10 Biochemistry of primary headaches -- 11 Pathophysiology of migraine: current status and future directions -- 12 Pathophysiology of TTH: current status and future directions -- 13 Pathophysiology of cluster headache: current status and future directions -- 14 Pathophysiology of MOH: current status and future directions. 330 $aThis book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches ? migraine, tension-type headache (TTH), and cluster headache ? and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system and cortical spreading depression in migraine. Detailed information is provided on insights into primary headaches from imaging studies, including functional magnetic resonance imaging and positron emission tomography and on their neurophysiology and biochemistry. A further series of important chapters describe present knowledge of the pathophysiology of each specific type of headache and consider future directions. Written by acknowledged experts in their fields from Europe and the United States, clinicians and students will find Pathophysiology of Headaches to be an excellent source of up-to-date information on why patients experience headaches. In addition, it will be of value for pain researchers investigating the underlying mechanisms of headache. 410 0$aHeadache,$x2197-652X 606 $aInternal medicine 606 $aNeurology 606 $aNeurobiology 606 $aPain medicine 606 $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 606 $aPain Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H47003 615 0$aInternal medicine. 615 0$aNeurology. 615 0$aNeurobiology. 615 0$aPain medicine. 615 14$aInternal Medicine. 615 24$aNeurology. 615 24$aNeurobiology. 615 24$aPain Medicine. 676 $a573.8 676 $a610 676 $a616 676 $a616.0472 676 $a616.8 702 $aAshina$b Messoud$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGeppetti$b Pierangelo$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300218503321 996 $aPathophysiology of Headaches$92504771 997 $aUNINA