LEADER 04710nam 22006735 450 001 9910300208803321 005 20200629234146.0 010 $a1-4939-1526-6 024 7 $a10.1007/978-1-4939-1526-2 035 $a(CKB)3710000000268247 035 $a(EBL)1965061 035 $a(OCoLC)908083123 035 $a(SSID)ssj0001372764 035 $a(PQKBManifestationID)11798061 035 $a(PQKBTitleCode)TC0001372764 035 $a(PQKBWorkID)11312561 035 $a(PQKB)11450651 035 $a(DE-He213)978-1-4939-1526-2 035 $a(MiAaPQ)EBC1965061 035 $a(PPN)182093417 035 $a(EXLCZ)993710000000268247 100 $a20141024d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRaynaud?s Phenomenon $eA Guide to Pathogenesis and Treatment /$fedited by Fredrick M. Wigley, Ariane L. Herrick, Nicholas A. Flavahan 205 $a1st ed. 2015. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2015. 215 $a1 online resource (400 p.) 300 $aDescription based upon print version of record. 311 $a1-4939-1525-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aHistorical perspective of Raynaud's phenomenon -- definition, nomenclature and diagnostic criteria -- Epidemiology of Raynaud?s Phenomenon -- Thermoregulation: The Normal Structure and Function of the Cutaneous Vascular System -- Pathophysiological Regulation of the Cutaneous Vascular System in Raynaud?s Phenomenon -- Primary Raynaud?s Phenomenon -- Raynaud Phenomenon In The Pediatric Age.-Secondary Raynaud?s phenomenon -- Traumatic Vasospastic Disease -- Other Secondary Causes -- Raynaud?s Mimics -- Nailfold Capillaries.-Non-Invasive methods of assessing Raynaud?s phenomenon -- Angiography -- Autoantibodies in Raynaud?s Phenomenon -- Systemic Vasospasm -- Clinical Outcome Measures in Raynaud?s Phenomenon -- Design and reporting of randomised controlled trials for Raynaud?s phenomenon -- Non-drug Approaches to Treating Raynaud?s Phenomenon -- Drug Treatment of Raynaud?s Phenomenon -- Management of digital ischemia -- Surgical Management -- Practical Approaches to Treatment: Case Studies. 330 $aRaynaud?s Phenomenon: A Guide to Pathogenesis and Treatment comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists alike.   In the last decade, there have been important advances not only in understanding the pathophysiology of Raynaud?s Phenomenon (RP), but also in developing diagnostic methods and effective drug and non-drug therapies.  Thoroughly discussing the various manifestations of RP, including childhood RP, RP secondary to connective tissue disease, and a variety of other associated disorders that include vascular perturbation that mimics RP, this title provides a wealth of new information available on normal and abnormal thermoregulation and helps physicians identify the best therapeutic approaches to treating RP.  The work offers differential diagnosis options, reviews potential causes -- such as autoimmune disease, industrial trauma, drugs, and metabolic causes --  and provides clear recommendations for therapy.  Engaging readers with case vignettes and a plethora of visual aids, Raynaud?s Phenomenon: A Guide to Pathogenesis and Treatment is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to physicians, patients, and individuals dealing with these disease processes. 606 $aRheumatology 606 $aInternal medicine 606 $aDermatology 606 $aRheumatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33170 606 $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002 606 $aDermatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H1900X 615 0$aRheumatology. 615 0$aInternal medicine. 615 0$aDermatology. 615 14$aRheumatology. 615 24$aInternal Medicine. 615 24$aDermatology. 676 $a610 676 $a616 676 $a616.5 676 $a616723 702 $aWigley$b Fredrick M$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHerrick$b Ariane L$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aFlavahan$b Nicholas A$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300208803321 996 $aRaynaud?s Phenomenon$91764288 997 $aUNINA