LEADER 04718nam 22006735 450 001 9910300192203321 005 20200630060619.0 010 $a3-662-45074-7 024 7 $a10.1007/978-3-662-45074-1 035 $a(CKB)3710000000343734 035 $a(EBL)1973752 035 $a(SSID)ssj0001424415 035 $a(PQKBManifestationID)11891208 035 $a(PQKBTitleCode)TC0001424415 035 $a(PQKBWorkID)11367001 035 $a(PQKB)10849731 035 $a(DE-He213)978-3-662-45074-1 035 $a(MiAaPQ)EBC1973752 035 $a(PPN)183517229 035 $a(EXLCZ)993710000000343734 100 $a20150130d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAutonomic Innervation of the Heart$b[electronic resource] $eRole of Molecular Imaging /$fedited by Riemer H.J.A. Slart, René A. Tio, Philip H. Elsinga, Markus Schwaiger 205 $a1st ed. 2015. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2015. 215 $a1 online resource (469 p.) 300 $aDescription based upon print version of record. 311 $a3-662-45073-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction -- Autonomic nervous system of the heart -- Pathophysiology of the autonomic nervous system of the heart -- Tracers for Presynaptic Cardiac Innervation -- Tracers of Adrenergic Receptors -- Tracers of the Parasympathetic System -- Radiopharmaceuticals production under GMP -- Physics of PET-CT and SPECT-CT -- Kinetics & software PET -- SPECT-CT imaging of autonomic innervation in heart diseases -- PET-CT imaging of autonomic innervation in heart diseases -- Imaging ischemic heart disease -- Imaging diabetes mellitus -- Imaging heart failure -- Imaging amyloidosis -- Imaging heart transplantation -- Imaging ventricular arrhythmias -- Guided therapy & imaging -- Imaging the functional brain-heart axis: neurodegenerative diseases -- Imaging the functional brain-heart axis: mental stress & anxiety -- Imaging cardiotoxicity: the effects of chemo- and mono-clonal antibody therapy on autonomic innervation -- Imaging cardiotoxicity: the effect of radiotherapy on autonomic innervation -- Summary and Future Perspectives: PET-MRI Imaging of cardiac Innervation, fluorescence imaging of cardiac innervation -- Epilog -- Index. 330 $aThis book explains in detail the potential value of the hybrid modalities, SPECT-CT and PET-CT, in the imaging of cardiac innervation in a wide range of conditions and diseases, including ischemic heart disease, diabetes mellitus, heart failure, amyloidosis, heart transplantation, and ventricular arrhythmias. Imaging of the brain-heart axis in neurodegenerative disease and stress and of cardiotoxicity is also discussed. The roles of the various available tracers are fully considered, and individual chapters address radiopharmaceutical development under GMP, imaging physics, and kinetic modeling software. Highly relevant background information is included on the autonomic nervous system of the heart and its pathophysiology, and in addition future perspectives are discussed. Awareness of the importance of autonomic innervation of the heart for the optimal management of cardiac patients is growing, and there is an evident need for objective measurement techniques or imaging modalities. In this context, Autonomic Innervation of the Heart will be of wide interest to clinicians, researchers, and industry. 606 $aRadiology 606 $aNuclear medicine 606 $aCardiology 606 $aDiagnostic Radiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H29013 606 $aNuclear Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H29048 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 615 0$aRadiology. 615 0$aNuclear medicine. 615 0$aCardiology. 615 14$aDiagnostic Radiology. 615 24$aNuclear Medicine. 615 24$aCardiology. 676 $a610 676 $a616.07548 676 $a616.0757 676 $a616.12 702 $aSlart$b Riemer H.J.A$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aTio$b René A$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aElsinga$b Philip H$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSchwaiger$b Markus$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300192203321 996 $aAutonomic Innervation of the Heart$91759954 997 $aUNINA