LEADER 04304nam 22007695 450 001 9910300191703321 005 20230810184158.0 010 $a3-319-13957-6 024 7 $a10.1007/978-3-319-13957-9 035 $a(CKB)3710000000343733 035 $a(EBL)1973834 035 $a(SSID)ssj0001424567 035 $a(PQKBManifestationID)11844610 035 $a(PQKBTitleCode)TC0001424567 035 $a(PQKBWorkID)11363962 035 $a(PQKB)11446978 035 $a(DE-He213)978-3-319-13957-9 035 $a(MiAaPQ)EBC1973834 035 $a(PPN)183520629 035 $a(EXLCZ)993710000000343733 100 $a20150130d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPre-Analytics of Pathological Specimens in Oncology /$fedited by Manfred Dietel, Christian Wittekind, Gianni Bussolati, Moritz Winterfeld 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (134 p.) 225 1 $aRecent Results in Cancer Research,$x2197-6767 ;$v199 300 $aDescription based upon print version of record. 311 $a3-319-13956-8 327 $aWhat Is Pre-Analytics in Surgical Pathology? -- Histologic Validation of Vacuum Sealed Formalin -- Free Tissue Preservation and Transport System -- Pre-Analytics and Molecular Pathology -- Experiences in Vacuum Preparation of Routine Specimens -- Tissue Heterogeneity as a Pre-Analytical Source of Variability -- Vacuum Fixation of Breast Specimens Before Grossing -- How Do Short Fixation and Rapid Microwave Processing Affect Her2 Testing? -- Current Projects in Pre-Analytics ? Where to Go? -- Nucleic Acid Extraction from FFPE Tissue as Critical Preanalytic Step for NGS Applications -- Experiences With Pre-Analytics of Lung Specimen -- Experiences With Pre-Analytics of GI-Specimen -- Bone Marrow Work-Up -- Two-Temperature Fixation Preserves Activation Status with High Efficiency -- Towards the Lean Lab. The Industry Challenge.  . 330 $aThis book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase ? the period from surgical removal of tissue to the start of pathological processing ? have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up. 410 0$aRecent Results in Cancer Research,$x2197-6767 ;$v199 606 $aOncology 606 $aPathology 606 $aSurgery 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aOncology 606 $aPathology 606 $aSurgery 606 $aBiomedical Research 615 0$aOncology. 615 0$aPathology. 615 0$aSurgery. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aOncology. 615 24$aPathology. 615 24$aSurgery. 615 24$aBiomedical Research. 676 $a610 676 $a610724 676 $a616.07 676 $a616994 676 $a617 702 $aDietel$b Manfred$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWittekind$b Christian$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBussolati$b Gianni$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWinterfeld$b Moritz$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300191703321 996 $aPre-Analytics of Pathological Specimens in Oncology$91835258 997 $aUNINA