LEADER 04117nam 22006735 450 001 9910300189403321 005 20200630085957.0 010 $a3-319-11044-6 024 7 $a10.1007/978-3-319-11044-8 035 $a(CKB)3710000000291503 035 $a(EBL)1967266 035 $a(OCoLC)908086708 035 $a(SSID)ssj0001386334 035 $a(PQKBManifestationID)11814643 035 $a(PQKBTitleCode)TC0001386334 035 $a(PQKBWorkID)11374684 035 $a(PQKB)10686630 035 $a(DE-He213)978-3-319-11044-8 035 $a(MiAaPQ)EBC1967266 035 $a(PPN)183093089 035 $a(EXLCZ)993710000000291503 100 $a20141120d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAntiphospholipid Antibody Syndrome $eFrom Bench to Bedside /$fedited by Pier Luigi Meroni 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (273 p.) 225 1 $aRare Diseases of the Immune System,$x2282-6505 ;$v0 300 $aDescription based upon print version of record. 311 $a3-319-11043-8 320 $aIncludes bibliographical references and index. 327 $aForeword -- Preface -- 1 APS: Introductory notes -- 2 Immunology and Genetics of APS -- 3 The paradox of the lupus anticoagulant -- 4 The pathogenic mechanism(s) for APS-mediated thrombosis -- 5 The pathogenic mechanism(s) for APS-mediated pregnancy loss -- 6 Classification criteria -- 7 Non-classification criteria -- 8 Obstetric APS -- 9 APS and the nervous system -- 10 APS and renal involvement -- 11 Non-thrombotic hematologic manifestations in APS -- 12 Heart and APS -- 13 Skin and APS -- 14 Additional organs involved in APS (eye, ENT, GI, endocrine) -- 15 Treatment of thrombosis -- 16 Treatment of pregnancy complications -- 17 Asymptomatic carries of APS -- 18 New treatments -- 19 Secondary APS -- 20   Catastrophic APS. 330 $aThis book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss or complications are explained. The main clinical manifestations and classification criteria are described and diagnostic tools, identified. Close attention is paid to the nature of the involvement of other organs or organ systems in APS, including the nervous, endocrine, hematologic, cardiovascular, and gastrointestinal systems, the kidney, the skin, and the eye. Specific chapters describe the treatment of the different symptoms, the preventive therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome. 410 0$aRare Diseases of the Immune System,$x2282-6505 ;$v0 606 $aHematology 606 $aRheumatology 606 $aGynecology  606 $aHematology$3https://scigraph.springernature.com/ontologies/product-market-codes/H3307X 606 $aRheumatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33170 606 $aGynecology$3https://scigraph.springernature.com/ontologies/product-market-codes/H26006 615 0$aHematology. 615 0$aRheumatology. 615 0$aGynecology . 615 14$aHematology. 615 24$aRheumatology. 615 24$aGynecology. 676 $a610 676 $a616.15 676 $a616723 676 $a618.1 702 $aMeroni$b Pier Luigi$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300189403321 996 $aAntiphospholipid Antibody Syndrome$91759898 997 $aUNINA