LEADER 04666nam 22006735 450 001 9910300183603321 005 20200629194613.0 010 $a3-319-10711-9 024 7 $a10.1007/978-3-319-10711-0 035 $a(CKB)3710000000227390 035 $a(EBL)1802507 035 $a(SSID)ssj0001338769 035 $a(PQKBManifestationID)11776636 035 $a(PQKBTitleCode)TC0001338769 035 $a(PQKBWorkID)11345538 035 $a(PQKB)11312127 035 $a(DE-He213)978-3-319-10711-0 035 $a(MiAaPQ)EBC1802507 035 $a(PPN)180624350 035 $a(EXLCZ)993710000000227390 100 $a20140828d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aLipid Nanoparticles: Production, Characterization and Stability /$fby Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (105 p.) 225 1 $aSpringerBriefs in Pharmaceutical Science & Drug Development,$x1864-8118 300 $aDescription based upon print version of record. 311 $a1-322-13824-9 311 $a3-319-10710-0 320 $aIncludes bibliographical references. 327 $aIntroduction -- Composition and structure -- Production techniques -- Characterization -- Physicochemical stability. 330 $aWhat are lipid nanoparticles?  How are they structured?  How are they formed? What techniques are best to characterize them?  How great is their potential as drug delivery systems?  These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A comprehensive description of the current understanding of synthesis, characterization, stability optimization and drug incorporation of solid lipid nanoparticles is provided. Nanoparticles have attracted great interest over the past few decades with almost exponential growth in their research and application. Their small particle size and subsequent high surface area make them ideal in many uses, but particularly as drug carrier systems. Nanoparticles made from lipids are especially attractive because of their enhanced biocompatibility imparted by the lipid. The work provides a detailed description of the types of lipid nanoparticles available (e.g. SLN, NLC, LDC, PLN) and how they range from imperfect crystalline to amorphous in structure. Current thoughts on where drugs are situated (e.g. in the core, or at the interface) and how this can be manipulated are discussed.  The many techniques for production, including the author?s own variant of microwave heating, are fully discussed. Techniques for measuring arguably the most important characteristics of particle size and polydispersity are discussed, along with techniques to measure crystallinity, shape and drug capacity.  Finally, a full chapter on techniques for measuring stability, both in the absence and presence of drugs, is discussed, along with suggestions on how to optimize that stability. This work appeals to students of colloid science, practitioners of research into drug delivery and academics alike. 410 0$aSpringerBriefs in Pharmaceutical Science & Drug Development,$x1864-8118 606 $aPharmaceutical technology 606 $aBiotechnology 606 $aLipids 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 606 $aBiotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/C12002 606 $aLipidology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14080 615 0$aPharmaceutical technology. 615 0$aBiotechnology. 615 0$aLipids. 615 14$aPharmaceutical Sciences/Technology. 615 24$aBiotechnology. 615 24$aLipidology. 676 $a572.57 700 $aShah$b Rohan$4aut$4http://id.loc.gov/vocabulary/relators/aut$01059806 702 $aEldridge$b Daniel$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aPalombo$b Enzo$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aHarding$b Ian$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910300183603321 996 $aLipid Nanoparticles: Production, Characterization and Stability$92508262 997 $aUNINA