LEADER 05212nam 22005655 450 001 9910300164603321 005 20200706084744.0 010 $a3-319-19560-3 024 7 $a10.1007/978-3-319-19560-5 035 $a(CKB)3710000000452138 035 $a(EBL)3567837 035 $a(SSID)ssj0001534810 035 $a(PQKBManifestationID)11875474 035 $a(PQKBTitleCode)TC0001534810 035 $a(PQKBWorkID)11497471 035 $a(PQKB)11110796 035 $a(DE-He213)978-3-319-19560-5 035 $a(MiAaPQ)EBC3567837 035 $a(PPN)187685312 035 $a(EXLCZ)993710000000452138 100 $a20150720d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aOsteoarthritis $ePathogenesis, Diagnosis, Available Treatments, Drug Safety, Regenerative and Precision Medicine /$fedited by Mohit Kapoor, Nizar N. Mahomed 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Adis,$d2015. 215 $a1 online resource (283 p.) 300 $aDescription based upon print version of record. 311 $a3-319-19559-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a1. Pathogenesis of Osteoarthritis -- 2. Hip and Knee Osteoarthritis -- 3. Shoulder and Elbow Osteoarthritis -- 4. Lumbar Spine Osteoarthritis -- 5. Ankle Arthritis -- 6. Hand and Wrist Osteoarthritis -- 7. Imaging in Osteoarthritis -- 8. Osteoarthritis ? Joint Conservation Strategies -- 9. Osteoarthritis Biomarkers -- 10. Drug/Agent Treatments for Osteoarthritis- Present and Future -- 11. Safety Profile of Current OA Therapies: Evidence from Clinical Trials -- 12. Regenerative Medicine Approaches for Treatment of Osteoarthritis -- 13. Precision Medicine for Osteoarthritis. 330 $aThis comprehensive book grants readers exclusive insight into current advancements in the field of osteoarthritis (OA). Contributions from leading scientists and clinicians provide a detailed introduction into current understanding of the pathogenesis of OA, different joint structures affected by this debilitating disease (hip, knee, elbow, shoulder, foot, ankle, hand, wrist, and spine), current knowledge and practice in imaging, joint conservative strategies, OA biomarkers as well as currently available treatments, their safety profile and future therapeutic targets. This book further discusses the potential of regenerative therapies and recent advances in OA Personalized Medicine, and how collection of OA patients? phenotypic, genetic and proteomic data is able to direct treatment strategies through Bio-Informatics. Dr. Mohit Kapoor is an Associate Professor in the Department of Surgery and the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Canada. He heads the cartilage biology research group within the Arthritis Program at the Toronto Western Research Institute, University Health Network, Toronto. His research program is directed towards understanding the complex pathophysiology of OA and identifying new therapeutic strategies to identify and counteract the destruction of the articular cartilage during OA. Specifically, his research is focused towards (a) understanding the mechanisms that are essential for maintaining articular cartilage homeostasis and mechanisms that trigger cell death and articular cartilage damage, and (b) identifying new OA biomarkers. Dr. Kapoor has published over 50 research articles, reviews and book chapters and is a recipient of several prestigious research awards. Dr. Nizar Mahomed is head of the Division of Orthopaedic Surgery at the University Health Network and Professor in the Department of Surgery at the University of Toronto, Canada. He is Nicki and Bryce Douglas Chair and Smith & Nephew Chair in Orthopaedic Surgery. Clinically he focuses on complex primary and revision hip and knee replacement surgery. He has over 100 publications and book chapters.  His research interests are in the areas of health systems research focusing on models of care for orthopaedic conditions and translational research looking at regenerative options for OA. Dr. Mahomed has received several awards for his research and is the recipient of the first CIHR-CMAJ Top Canadian Achievements in Health Research Award. As Medical Director of the Arthritis Program at University Health Network, he leads the largest integrated Arthritis Program in Canada. 606 $aRheumatology 606 $aPharmacy 606 $aRheumatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33170 606 $aDrug Safety and Pharmacovigilance$3https://scigraph.springernature.com/ontologies/product-market-codes/H69010 615 0$aRheumatology. 615 0$aPharmacy. 615 14$aRheumatology. 615 24$aDrug Safety and Pharmacovigilance. 676 $a610 702 $aKapoor$b Mohit$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMahomed$b Nizar N$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300164603321 996 $aOsteoarthritis$91864472 997 $aUNINA