LEADER 04071nam 2200661Ia 450 001 9910782122803321 005 20230417212931.0 010 $a1-281-86607-5 010 $a9786611866075 010 $a1-84816-161-1 035 $a(CKB)1000000000537744 035 $a(EBL)1681236 035 $a(OCoLC)879025048 035 $a(SSID)ssj0000096942 035 $a(PQKBManifestationID)11116487 035 $a(PQKBTitleCode)TC0000096942 035 $a(PQKBWorkID)10082752 035 $a(PQKB)10680098 035 $a(MiAaPQ)EBC1681236 035 $a(WSP)0000P233 035 $a(Au-PeEL)EBL1681236 035 $a(CaPaEBR)ebr10255496 035 $a(CaONFJC)MIL186607 035 $a(EXLCZ)991000000000537744 100 $a20020311h20012000 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe activities of bacterial pathogens in vivo $ebased on contributions to a Royal Society discussion meeting : London, UK : meeting held on 20-21 October 1999 /$feditors, H. Smith [et al.] 210 $aLondon $cImperial College Press$d2001, c2000 215 $a1 online resource (410 pages) $cillustrations 300 $aOriginally published in: Philosophical transactions of the Royal Society series B. 2000. 311 0 $a1-86094-272-5 320 $aIncludes bibliographical references and index. 327 $aPreface ; Introduction ; Questions about the Behaviour of Bacterial Pathogens in Vivo ; DNA Topology and Adaptation of Salmonella typhimurium to an Intracellular Environment ; New Methods for Studying Bacterial Behaviour in Vivo The Pathogenesis of Shigella flexneri Infection: Lessons from in Vitro and in Vivo Studies Detection and Analysis of Gene Expression During Infection by in Vivo Expression Technology ; Measurement of Bacterial Gene Expression in Vivo Identification and Analysis of Bacterial Virulence Genes in Vivo Salmonella Interactions with Host Cells: In Vitro to in Vivo ; Impact of the New Methods ; In Vivo Gene Expression and the Adaptive Response: From Pathogenesis to Vaccines and Antimicrobials Challenge of Investigating Biologically Relevant Functions of Virulence Factors in Bacterial Pathogens Virulence Gene Regulation Inside and Outside ; Evidence for Operation in Vivo of Aspects of Pathogenicity Revealed by Recent Work in Vitro: Potential Use of New Methods Quorum Sensing and the Population-dependent Control of Virulence Type III Secretion: A Bacterial Device for Close Combat with Cells of Their Eukaryotic Host ; Evolution of Microbial Pathogens ; The Immune Responses to Bacterial Antigens Encountered in Vivo at Mucosal Surfaces ; Index 330 $aPathogenic bacteria have unique biological properties, which enable them to invade a host and cause sickness. The molecular bases of these biological properties are the determinants of pathogenicity, and the research objectives are to recognize them, identify them chemically and relate their structure to function. Most of our present knowledge comes from studies with cultures in vitro. 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Introduction -- Part I. Osteoarthritis of the knee or hip -- 2. Epidemiology, pathogenesis, and clinical aspects -- 3. Therapeutic options -- Part II. Functional decline -- 4. Risk factors for functional decline -- 5. Neuromuscular mechanisms explaining functional decline -- 6. Behavioral mechanisms explaining functional decline -- Part III. Exercise therapy -- 7.Regular exercise therapy -- 8. Exercise aiming at neuromuscular mechanisms -- 9. Exercise aiming at behavioral mechanisms -- 10. Comorbidity, overweight, and exercise -- 11. Concluding remarks. 330 $aOsteoarthritis (OA) is among the top 10 of most disabling diseases in the Western world. It is the major cause of pain and disability among the elderly. This book provides a contextual review of recent research on neuromuscular factors and behavioral risk factors for functional decline in OA, with a special emphasis on explanatory mechanisms. In addition, the book discusses innovative approaches to exercise and physical activity in OA, derived from research on behavioral and neuromuscular risk factors for functional decline in OA. Recent research has shown that neuromuscular factors (such as muscle strength, joint laxity) and behavioral factors (such as avoidance of activity, depressed mood) predict pain and disability in OA. Furthermore, exercise and physical activity are among the dominant interventions aiming at reducing pain and disability, and innovative interventions targeting neuromuscular and behavioral interventions have been recently developed. 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