LEADER 04598nam 22006735 450 001 9910300075803321 005 20200703095618.0 010 $a1-4614-8915-6 024 7 $a10.1007/978-1-4614-8915-3 035 $a(CKB)3710000000073385 035 $a(EBL)1592923 035 $a(OCoLC)868915394 035 $a(SSID)ssj0001067548 035 $a(PQKBManifestationID)11567117 035 $a(PQKBTitleCode)TC0001067548 035 $a(PQKBWorkID)11093074 035 $a(PQKB)10780313 035 $a(MiAaPQ)EBC1592923 035 $a(DE-He213)978-1-4614-8915-3 035 $a(PPN)176100059 035 $a(EXLCZ)993710000000073385 100 $a20131108d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aImmunological Mechanisms and Therapies in Brain Injuries and Stroke /$fedited by Jun Chen, Xiaoming Hu, Mary Stenzel-Poore, John H. Zhang 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (390 p.) 225 1 $aSpringer Series in Translational Stroke Research,$x2363-958X ;$v6 300 $aDescription based upon print version of record. 311 $a1-4614-8914-8 320 $aIncludes bibliographical references and index. 327 $aOld dogmas, surprising complexities, and novel therapeutic targets -- The critical roles of immune cells in acute brain injuries -- Vascular Inflammation in Ischemic Stroke: Adhesion Receptors Controlling Leukocyte-Endothelial Interactions -- Immune Cell-Derived Free Radicals in Acute Brain Injury -- The complement cascade in acute brain injury -- Matrix Metalloproteinases as an Inflammatory Mediator in the Neurovascular Unit -- Toll-Like Receptors in Ischemic Stroke and other Acute Brain Injuries -- Ion Transporters in Microglial Function: New therapeutic targets for neuroinflammation in ischemic stroke? -- Inflammation After Acute Brain Injuries Affects the Developing Brain Differently than the Adult Brain -- Systemic Immune Responses after Experimental Stroke -- Infectious Burden and Risk of Stroke -- Inflammatory Biomarkers in Patients with Acute Brain Injuries -- In vivo Imaging of Neuroinflammation in Acute Brain Injury -- Inflammation as a therapeutic target after subarachnoid hemorrhage: advances and challenges -- Minocycline, a Tetracycline Derivative, as a Potential Protective Agent for Acute Stroke -- Tolerization to Brain and Vascular Antigens: Targeting Autoimmunity after Acute Brain Injuries and Preventing Stroke -- The Role of PPARg in Stroke -- CD36: an inflammatory mediator in acute brain injury -- Cool Down the Inflammation:  Hypothermia as a Therapeutic Strategy for Acute Brain Injuries -- Index. 330 $aRecent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system.  This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes. 410 0$aSpringer Series in Translational Stroke Research,$x2363-958X ;$v6 606 $aNeurosciences 606 $aNeurology  606 $aNeurobiology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 615 0$aNeurosciences. 615 0$aNeurology . 615 0$aNeurobiology. 615 14$aNeurosciences. 615 24$aNeurology. 615 24$aNeurobiology. 676 $a616.81 702 $aChen$b Jun$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHu$b Xiaoming$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aStenzel-Poore$b Mary$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aZhang$b John H$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300075803321 996 $aImmunological Mechanisms and Therapies in Brain Injuries and Stroke$91521772 997 $aUNINA