LEADER 03689oam 2200457 450 001 9910300075203321 005 20190911112725.0 010 $a3-319-01472-2 024 7 $a10.1007/978-3-319-01472-2 035 $a(OCoLC)861559045 035 $a(MiFhGG)GVRL6VTD 035 $a(EXLCZ)993710000000025263 100 $a20130829d2014 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 10$aEpidemiology of human congenital malformations /$fBengt Kallen 205 $a1st ed. 2014. 210 1$aCham [Switzerland] :$cSpringer,$d2014. 215 $a1 online resource (ix, 170 pages) $cillustrations (some color) 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a3-319-01471-4 320 $aIncludes bibliographical references and index. 327 $aA Short History of Birth Defect Epidemiology -- Genetic and Non-genetic Factors in the Origin of Congenital Malformations -- Ascertainment of Children with Congenital Malformations -- Statistical Considerations -- Epidemiological Methods -- Neural Tube Defects -- Microcephaly -- Hydrocephaly -- Agenesis of Corpus Callosum and Holoprosencephaly -- Severe Eye Malformations -- Severe Ear Malformations -- Cardiovascular Defects -- Orofacial Clefts -- Atresia or Stenosis of the Alimentary Tract -- Pyloric Stenosis -- Malrotation of the Gut -- Megacolon -- Hypospadias -- Epispadias, Cloacal and Bladder Exstrophy -- Severe Renal Malformations -- Posterior Urethral Valve -- Pes Equinovarus -- Other Foot Deformities than Pes Equinovarus -- Polydactyly and Syndactyly -- Limb Reduction Defects -- Craniostenosis -- Diaphragmatic Hernia -- Abdominal Wall Defects -- Children with multiple malformations -- ?Syndromes? -- Down Syndrome -- Explanation and Prevention of Birth Defects -- Eight Commandments: Rules for the Interpretation of Birth Defect Epidemiological Studies. 330 $aThe subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest. The structure of the analysis is such that it excludes studies of, for instance, nutrition, alcohol or street drug use and many other lifestyle factors where prospective information or independent register information is difficult or impossible to obtain. Epidemiology of Human Congenital Malformations culminates with a discussion on how the presence of malformations can be explained and various possibilities for the prevention of birth defects. Moreover, it will include a series of instructions on how to read epidemiological literature in this field making it an essential resource both for those currently working in the field of reproductive epidemiology or those intending to enter it. It will additionally be useful for doctors working with malformations, either as obstetricians, neonatologists or pediatricians. 606 $aAbnormalities, Human$xEpidemiology 615 0$aAbnormalities, Human$xEpidemiology. 676 $a610 676 $a612.6 676 $a613 676 $a614.4 700 $aKällén$b Bengt$4aut$4http://id.loc.gov/vocabulary/relators/aut$0755849 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910300075203321 996 $aEpidemiology of Human Congenital Malformations$91523184 997 $aUNINA