LEADER 05450nam 22006855 450 001 9910300074803321 005 20200703095842.0 010 $a1-4614-8833-8 024 7 $a10.1007/978-1-4614-8833-0 035 $a(CKB)2550000001151414 035 $a(EBL)1538492 035 $a(SSID)ssj0001049352 035 $a(PQKBManifestationID)11599520 035 $a(PQKBTitleCode)TC0001049352 035 $a(PQKBWorkID)11017345 035 $a(PQKB)10788103 035 $a(MiAaPQ)EBC1538492 035 $a(DE-He213)978-1-4614-8833-0 035 $a(PPN)176099816 035 $a(EXLCZ)992550000001151414 100 $a20131019d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAlcohol Use Disorders and the Lung $eA Clinical and Pathophysiological Approach /$fedited by David M. Guidot, Ashish J. Mehta 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Humana,$d2014. 215 $a1 online resource (253 p.) 225 1 $aRespiratory Medicine,$x2197-7372 300 $aDescription based upon print version of record. 311 $a1-4614-8832-X 320 $aIncludes bibliographical references and index. 327 $aA Brief History of Alcohol Use and Abuse in Human History -- Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations -- Current Definitions of Alcohol Use Disorders and the Use of Validated Questionnaires in Clinical Practice and Research -- The Epidemiology of Alcohol Abuse and Pneumonia -- The Epidemiology of Alcohol and Acute Respiratory Distress Syndrome -- Alcohol, the Upper Airway, and Mucociliary Dysfunction in the Conducting Airways -- Alcohol and the Alveolar Macrophage -- Alcohol and the Alveolar Epithelium -- Alcohol-Mediated Oxidative Stress in the Airway: The Unique Role of Thiol Depletion -- Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments -- Alcohol Impairment of Granulocyte Function During Lung Infection -- Disruption in the Dynamic Balance Between Transforming Growth Factor-? and Granulocyte/Macrophage Colony-stimulating Factor Signaling within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function -- Alcohol-mediated Zinc Deficiency within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung -- The Impact of Alcohol Abuse on Multiple Organ Dysfunction in the Surgical Patient -- Alcohol and HIV: Experimental and Clinical Evidence of Combined Impact on the Lung -- Maternal Alcohol Use and the Neonate. 330 $aAlcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach is an excellent resource for clinicians who care for individuals affected by alcohol use disorders in diverse settings. Although alcohol abuse alone does not cause acute lung injury, it renders the lung susceptible to dysfunction in response to the inflammatory stresses of sepsis, trauma, and other clinical conditions recognized to cause acute lung injury. In parallel, these same pathophysiological effects of alcohol abuse significantly increase the risk of a wide range of serious lung infections. Many clinicians involved in the primary treatment of alcohol use disorders, such as addiction psychiatrists, will find this text of interest as it will expand their understanding of the health consequences of alcohol use disorders. In parallel, clinicians who specialize in pulmonary and/or critical care medicine will have a unique resource that provides a comprehensive review of the pathophysiology of alcohol-related lung disorders and insights into evolving therapeutic options in these vulnerable individuals. Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach fills a gap in the literature and presents the evolving clinical research that may soon lead to novel therapies that can improve lung health in individuals with alcohol use disorders and co-existing conditions such as HIV infection. 410 0$aRespiratory Medicine,$x2197-7372 606 $aRespiratory organs?Diseases 606 $aCritical care medicine 606 $aPsychiatry 606 $aInternal medicine 606 $aPneumology/Respiratory System$3https://scigraph.springernature.com/ontologies/product-market-codes/H33134 606 $aIntensive / Critical Care Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H3100X 606 $aPsychiatry$3https://scigraph.springernature.com/ontologies/product-market-codes/H53003 606 $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002 615 0$aRespiratory organs?Diseases. 615 0$aCritical care medicine. 615 0$aPsychiatry. 615 0$aInternal medicine. 615 14$aPneumology/Respiratory System. 615 24$aIntensive / Critical Care Medicine. 615 24$aPsychiatry. 615 24$aInternal Medicine. 676 $a618.326861 702 $aGuidot$b David M$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMehta$b Ashish J$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300074803321 996 $aAlcohol Use Disorders and the Lung$91466419 997 $aUNINA