LEADER 04499nam 22007215 450 001 9910300073703321 005 20250609111428.0 010 $a9783540723141 010 $a3540723145 024 7 $a10.1007/978-3-540-72314-1 035 $a(CKB)3710000000025208 035 $a(EBL)1466300 035 $a(OCoLC)862048941 035 $a(SSID)ssj0001049353 035 $a(PQKBManifestationID)11652485 035 $a(PQKBTitleCode)TC0001049353 035 $a(PQKBWorkID)11019852 035 $a(PQKB)10200123 035 $a(MiAaPQ)EBC1466300 035 $a(DE-He213)978-3-540-72314-1 035 $a(PPN)176109994 035 $a(MiAaPQ)EBC4419006 035 $a(EXLCZ)993710000000025208 100 $a20131004d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aALERT - Adverse Late Effects of Cancer Treatment $eVolume 1: General Concepts and Specific Precepts /$fedited by Philip Rubin, Louis S. Constine, Lawrence B. Marks 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (321 p.) 225 1 $aRadiation Oncology 300 $aDescription based upon print version of record. 311 08$a9783540723134 311 08$a3540723137 320 $aIncludes bibliographical references. 327 $aBioContinuum of Effects of Multimodal Therapy -- BioMolecular Mechanisms and Pathways of Normal Tissue Damage -- BioPathology of Radiation and Chemotherapy -- BioImaging of the Longitudinal Normal Tissue Injury -- BioScoring Systems for Acute and Late Effects -- BioPediatric Complexities of Growth and Development -- Bioepidemiology -- BioGenetic and Host Implications -- Radiotherapy-Induced Biocarcinogenesis and Leukemogenesis -- BioManagement and BioPrevention.-BioSurveillance and Longitudinal Lifelong Guidelines -- Specific Precept: Medical Legal Issues: Malpractice Issues -- Insurance, Economics: Cost of Care -- Nursing -- Psychologic Issues -- Social Worker Issues: Quality of Life and Activities of Daily Living. 330 $aThe literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT ? Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 1 of this two-volume work focuses on the general concepts and principles relevant to late effects and on the dynamic interplay of molecular, cytologic and histopathologic events that lead to altered physiologic and metabolic functions and their clinical manifestations. Chapters are also included on legal issues, economic aspects, nursing, psychological issues and quality of life. 410 0$aRadiation Oncology 606 $aRadiotherapy 606 $aRadiology 606 $aOncology 606 $aRadiotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H29056 606 $aImaging / Radiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H29005 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aDiagnostic Radiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H29013 615 0$aRadiotherapy. 615 0$aRadiology. 615 0$aOncology. 615 14$aRadiotherapy. 615 24$aImaging / Radiology. 615 24$aOncology. 615 24$aDiagnostic Radiology. 676 $a616.99406 702 $aRubin$b Philip$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aConstine$b Louis S.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMarks$b Lawrence B$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300073703321 996 $aALERT - Adverse Late Effects of Cancer Treatment$92494552 997 $aUNINA