LEADER 05918nam 22006615 450 001 9910300072803321 005 20200701174521.0 010 $a3-642-38971-6 024 7 $a10.1007/978-3-642-38971-9 035 $a(CKB)2550000001152843 035 $a(EBL)1592115 035 $a(OCoLC)896250356 035 $a(SSID)ssj0001049574 035 $a(PQKBManifestationID)11602098 035 $a(PQKBTitleCode)TC0001049574 035 $a(PQKBWorkID)11018884 035 $a(PQKB)11401405 035 $a(MiAaPQ)EBC1592115 035 $a(DE-He213)978-3-642-38971-9 035 $a(PPN)176112898 035 $a(EXLCZ)992550000001152843 100 $a20131028d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPediatric Germ Cell Tumors$b[electronic resource] $eBiology Treatment Survivorship /$fedited by A. Lindsay Frazier, James F. Amatruda 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (144 p.) 225 1 $aPediatric Oncology,$x1613-5318 ;$v1 300 $aDescription based upon print version of record. 311 $a3-642-38970-8 320 $aIncludes bibliographical references and index. 327 $a""Acknowledgements and Dedication""; ""Contents""; ""Introduction""; ""1: Biology of Germ Cell Tumors""; ""1.1 Introduction""; ""1.2 Embryology and Development""; ""1.3 Epigenetics: Genomic Imprinting and Methylation""; ""1.3.1 Studies Which Demonstrate That Epigenetic Changes in GCTs Reflect the Stage of Development of the Primordial Germ Cell at the Time of Malignant Transformation""; ""1.3.2 Studies Which Demonstrate That Epigenetic Changes in GCT Subtypes May Account for the Observed Differences in Clinical Behavior and Outcome""; ""1.4 Genomic Aberrations"" 327 $a""1.5 Transcriptome Analysis""""1.5.1 Messenger RNA Profiles Identify Differences Between Pediatric and Adult GCTs""; ""1.5.2 MicroRNA Profiles Identify Commonalities Shared by Pediatric and Adult GCTs""; ""1.6 Pathway and Proteomic Analysis""; ""References""; ""2: Epidemiology of Germ Cell Tumors""; ""2.1 Incidence and Survival""; ""2.2 International Incidence Rates""; ""2.2.1 Pediatric GCTs""; ""2.2.2 Adult Testicular GCTs""; ""2.2.3 Adult Ovarian GCTs""; ""2.3 US Incidence Rates""; ""2.3.1 Pediatric GCTs""; ""2.3.2 Adult Testicular GCTs""; ""2.3.3 Adult Ovarian GCTs"" 327 $a""2.3.4 Trends in Incidence Rates""""2.3.5 Survival""; ""2.4 Risk Factors for Pediatric Germ Cell Tumors""; ""2.4.1 Family History""; ""2.4.2 Cryptorchidism and Other Congenital Abnormalities""; ""2.4.3 Maternal Estrogen Levels""; ""2.4.4 Parental Exposure to Pesticides and Other Chemicals""; ""2.4.5 Parental Lifestyle Factors""; ""2.4.6 Birth Characteristics""; ""2.4.7 Genetic Susceptibility""; ""2.5 Risk Factors for Adult Testicular Germ Cell Tumors""; ""2.5.1 Family History""; ""2.5.2 Testicular Dysgenesis Syndrome""; ""2.5.3 Maternal Estrogen Exposures"" 327 $a""2.5.4 Pesticides and Other Endocrine-Disrupting Agents""""2.5.5 Maternal Lifestyle Factors During Pregnancy""; ""2.5.6 Birth Characteristics""; ""2.5.7 Genetic Susceptibility""; ""2.6 Risk Factors for Adult Ovarian Germ Cell Tumors""; ""2.7 Summary and Conclusions""; ""References""; ""3: Pathology of Germ Cell Tumors""; ""3.1 Yolk Sac Tumor""; ""3.1.1 Gross Appearance""; ""3.1.2 Microscopic Appearance""; ""3.1.3 Immunohistochemistry""; ""3.2 Seminoma""; ""3.2.1 Gross Appearance""; ""3.2.2 Microscopic Appearance""; ""3.2.3 Immunohistochemistry""; ""3.3 Embryonal Carcinoma"" 327 $a""3.3.1 Gross Appearance""""3.3.2 Microscopic Appearance""; ""3.3.3 Immunohistochemistry""; ""3.4 Mature and Immature Teratoma""; ""3.4.1 Gross Appearance""; ""3.4.2 Microscopic Appearance""; ""3.4.3 Immunohistochemistry""; ""3.5 Mixed Germ Cell Tumors""; ""References""; ""4: Clinical Treatment of Extracranial Pediatric Germ Cell Tumors""; ""4.1 Introduction""; ""4.2 Development and Evolution of Treatment Regimens for Malignant Germ Cell Tumors in Children""; ""4.2.1 The North American Experience""; ""4.2.2 The United Kingdom Experience""; ""4.2.3 The German Experience"" 327 $a""4.2.4 The French Experience"" 330 $aGerm cell tumors are relatively rare compared with other malignancies, and compilations of knowledge that encompass the entire spectrum of the disease are lacking. This textbook, written by the foremost authorities in the field, rectifies the situation by discussing in depth a broad range of topics, including biology, epidemiology, pathology, treatment, and late effects. Bearing in mind that germ cell tumors are most prevalent in the adolescent and young adult age group, causes of disease and treatment approaches in pediatric and adult patients are compared and contrasted. By spanning the entire life course, from prenatal origins of disease through to treatment in adults and late effects of treatment, the editors have produced a book that will be of interest to both pediatric and adult oncologists. 410 0$aPediatric Oncology,$x1613-5318 ;$v1 606 $aOncology   606 $aPediatrics 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aPediatrics$3https://scigraph.springernature.com/ontologies/product-market-codes/H49006 615 0$aOncology  . 615 0$aPediatrics. 615 14$aOncology. 615 24$aPediatrics. 676 $a618.92994 702 $aFrazier$b A. Lindsay$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aAmatruda$b James F$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300072803321 996 $aPediatric Germ Cell Tumors$91522361 997 $aUNINA