LEADER 04907nam 22006255 450 001 9910300065103321 005 20200706111742.0 010 $a4-431-54789-4 024 7 $a10.1007/978-4-431-54789-1 035 $a(CKB)3710000000224692 035 $a(EBL)1802673 035 $a(SSID)ssj0001338637 035 $a(PQKBManifestationID)11994243 035 $a(PQKBTitleCode)TC0001338637 035 $a(PQKBWorkID)11344615 035 $a(PQKB)11608907 035 $a(MiAaPQ)EBC1802673 035 $a(DE-He213)978-4-431-54789-1 035 $a(PPN)180621238 035 $a(EXLCZ)993710000000224692 100 $a20140821d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAutoimmune Liver Diseases $ePerspectives from Japan /$fedited by Hiromasa Ohira 205 $a1st ed. 2014. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2014. 215 $a1 online resource (303 p.) 300 $aDescription based upon print version of record. 311 $a1-322-17350-8 311 $a4-431-54788-6 320 $aIncludes bibliographical references and index. 327 $aPreface -- Part I Autoimmune Hepatitis.-  1 Pathogenesis of Autoimmune Hepatitis-. 2 Animal Models of Autoimmune Hepatitis -- 3 Epidemiology and Natural History in Japan -- 4 Histological Findings of Autoimmune Hepatitis -- 5 Diagnosis of Autoimmune Hepatitis -- 6 Acute Presentation of Autoimmune Hepatitis -- 7 Treatment of Autoimmune Hepatitis -- 8 Management Strategies for Autoimmune Hepatitis Treatment Non-Responders -- 9 Pediatric Autoimmune Hepatitis -- 10 Nonalcoholic Steatohepatitis -Autoimmune Hepatitis Overlap -- 11 IgG4-Related Autoimmune Hepatitis -- Part II Primary Biliary Cirrhosis -- 12 The Onset Mechanism of Primary Biliary Cirrhosis -- 13 Genetic Factors in Pathogenesis of Primary Biliary Cirrhosis -- 14 Animal Models of Primary Biliary Cirrhosis -- 15 Epidemiology and Natural History in Japan -- 16 New Histological Staging and Grading System for Primary Biliary Cirrhosis -- 17 Autoantibodies in Primary Biliary Cirrhosis -- 18 Diagnosis and UDCA Treatment of Primary Biliary Cirrhosis -- 19 Bezafibrate Treatment of Primary Biliary Cirrhosis -- 20 Management the Patients with Feature of Autoimmune Hepatitis -- 21 Liver Transplantation for Primary Biliary Cirrhosis  . 330 $aAutoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries. 606 $aGastroenterology  606 $aHepatology 606 $aInternal medicine 606 $aGastroenterology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33061 606 $aHepatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33088 606 $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002 615 0$aGastroenterology . 615 0$aHepatology. 615 0$aInternal medicine. 615 14$aGastroenterology. 615 24$aHepatology. 615 24$aInternal Medicine. 676 $a616 676 $a616.3/62079 702 $aOhira$b Hiromasa$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300065103321 996 $aAutoimmune Liver Diseases$91521949 997 $aUNINA