LEADER 04482nam 22007095 450 001 9910300061503321 005 20251113201511.0 010 $a3-642-54379-0 024 7 $a10.1007/978-3-642-54379-1 035 $a(CKB)3710000000119198 035 $a(EBL)1731263 035 $a(OCoLC)884014037 035 $a(SSID)ssj0001242738 035 $a(PQKBManifestationID)11827365 035 $a(PQKBTitleCode)TC0001242738 035 $a(PQKBWorkID)11260051 035 $a(PQKB)10353945 035 $a(MiAaPQ)EBC1731263 035 $a(DE-He213)978-3-642-54379-1 035 $a(PPN)17877930X 035 $a(EXLCZ)993710000000119198 100 $a20140527d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFilaggrin $eBasic Science, Epidemiology, Clinical Aspects and Management /$fedited by Jacob P. Thyssen, Howard I. Maibach 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (362 p.) 300 $aDescription based upon print version of record. 311 08$a3-642-54378-2 320 $aIncludes bibliographical references at the end of each chapters. 327 $aBASIC SCIENCE: Mutations in the Filaggrin Gene -- Morphology of Normal and Filaggrin Depleted Epidermis -- Function of Filaggrin and Its Metabolites -- Influence On Skin Lipids -- Inflammatory Driven Depletion of Filaggrin Proteins -- Animal Models -- In Vitro Models -- EPIDEMIOLOGY: Prevalence Rates In Different Races -- Gene-Environment Interactions -- Heterozygous Advantage -- FILAGGRIN AND SKIN DISEASE: Ichthyosis Vulgaris and Other Disorders of Cornification -- Atopic Dermatitis -- Allergic Contact Dermatitis -- Irritant Contact Dermatitis -- Hand Eczema -- Psoriasis -- Disorders In The Seborrheic Areas -- Infections -- Cancer and Tumors -- Autoimmune and Connective Tissue Disorders -- Pigmentation Disorders -- Sweat Gland Disorders -- Nails and Hair -- FILAGGRIN AND NON-CUTANEOUS DISEASE: Asthma -- Rhinitis -- Food Allergy -- Diabetes -- Cardiac Disease -- Inflammatory Bowel Disease -- Ophthalmic Disease -- Rheumatoid Arthritis -- Cancer -- Vitamin D -- MANAGEMENT. 330 $aFilaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes.  While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract.   Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum.    This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties. 606 $aDermatology 606 $aAllergy 606 $aRespiratory organs$xDiseases 606 $aOphthalmology 606 $aDermatology 606 $aAllergology 606 $aPneumology 606 $aOphthalmology 615 0$aDermatology. 615 0$aAllergy. 615 0$aRespiratory organs$xDiseases. 615 0$aOphthalmology. 615 14$aDermatology. 615 24$aAllergology. 615 24$aPneumology. 615 24$aOphthalmology. 676 $a610 676 $a614.5993 676 $a616.042 676 $a616.2 702 $aThyssen$b Jacob P$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMaibach$b Howard I$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300061503321 996 $aFilaggrin$91523106 997 $aUNINA