LEADER 03986oam 2200613 450 001 9910137088303321 005 20230621140048.0 010 $a9782889196449 035 $a(CKB)3710000000824754 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40472 035 $a(EXLCZ)993710000000824754 100 $a20191103h20152015 fy| 0 101 0 $aeng 135 $aurcn#---||||n 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAging, neurogenesis and neuroinflammation in hearing loss and protection /$fMarta Magariños, Marta Milo and Isabel Varela-Nieto 210 $cFrontiers Media SA$d2015 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d[2015] 210 4$d©2015 215 $a1 online resource (151 pages) $cillustrations (chiefly colour); digital file(s) 225 1 $aFrontiers Research Topics 311 08$aPrint version: 2889196445 320 $aIncludes bibliographical references. 330 3 $aWorldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies.There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease.In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes involved in ageing as senescence and autophagy, to molecules essential for hearing as IGF-1 and neurotrophins. Neuroinflammation takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Neurogenesis is also essential to understand the adult cochlea self-repair potential. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies. 410 0$aFrontiers research topics. 606 $aPresbycusis 606 $aVestibular apparatus 606 $aDeafness$xEtiology 606 $aDeafness$xTreatment 610 $aTGF-beta 610 $aNoise 610 $aHair cells 610 $aredox balance 610 $aspiral ganglion neurons 610 $aDrug delivery 610 $aARHL 610 $aAuditory Cortex 610 $aLipid homeostasis 610 $aInner ear 615 0$aPresbycusis. 615 0$aVestibular apparatus. 615 0$aDeafness$xEtiology. 615 0$aDeafness$xTreatment. 676 $a617.8 700 $aMarta Magarinos$4auth$01366880 702 $aMagariños$b Marta 702 $aMilo$b Marta 702 $aVarela-Nieto$b Isabel 801 2$bUkMaJRU 912 $a9910137088303321 996 $aAging, neurogenesis and neuroinflammation in hearing loss and protection$93389399 997 $aUNINA LEADER 03867nam 22007335 450 001 9910299968503321 005 20200707012725.0 010 $a1-4939-1844-3 024 7 $a10.1007/978-1-4939-1844-7 035 $a(CKB)3710000000269881 035 $a(SSID)ssj0001372638 035 $a(PQKBManifestationID)11888488 035 $a(PQKBTitleCode)TC0001372638 035 $a(PQKBWorkID)11304636 035 $a(PQKB)10302634 035 $a(DE-He213)978-1-4939-1844-7 035 $a(MiAaPQ)EBC6314948 035 $a(MiAaPQ)EBC5594391 035 $a(Au-PeEL)EBL5594391 035 $a(OCoLC)896821995 035 $a(PPN)182098788 035 $a(EXLCZ)993710000000269881 100 $a20141031d2014 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aFundamentals of Algebraic Topology /$fby Steven H. Weintraub 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (X, 163 p. 82 illus.) 225 1 $aGraduate Texts in Mathematics,$x0072-5285 ;$v270 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a1-4939-1843-5 320 $aIncludes bibliographical references and index. 327 $aPreface -- 1. The Basics -- 2. The Fundamental Group -- 3. Generalized Homology Theory -- 4. Ordinary Homology Theory -- 5. Singular Homology Theory -- 6. Manifolds -- 7. Homotopy Theory -- 8. Homotopy Theory -- A. Elementary Homological Algebra -- B. Bilinear Forms.- C. Categories and Functors -- Bibliography -- Index. 330 $aThis rapid and concise presentation of the essential ideas and results of algebraic topology follows the axiomatic foundations pioneered by Eilenberg and Steenrod. The approach of the book is pragmatic: while most proofs are given, those that are particularly long or technical are omitted, and results are stated in a form that emphasizes practical use over maximal generality. Moreover, to better reveal the logical structure of the subject, the separate roles of algebra and topology are illuminated. Assuming a background in point-set topology, Fundamentals of Algebraic Topology covers the canon of a first-year graduate course in algebraic topology: the fundamental group and covering spaces, homology and cohomology, CW complexes and manifolds, and a short introduction to homotopy theory. Readers wishing to deepen their knowledge of algebraic topology beyond the fundamentals are guided by a short but carefully annotated bibliography. 410 0$aGraduate Texts in Mathematics,$x0072-5285 ;$v270 606 $aAlgebraic topology 606 $aManifolds (Mathematics) 606 $aComplex manifolds 606 $aCategories (Mathematics) 606 $aAlgebra, Homological 606 $aAlgebraic Topology$3https://scigraph.springernature.com/ontologies/product-market-codes/M28019 606 $aManifolds and Cell Complexes (incl. Diff.Topology)$3https://scigraph.springernature.com/ontologies/product-market-codes/M28027 606 $aCategory Theory, Homological Algebra$3https://scigraph.springernature.com/ontologies/product-market-codes/M11035 615 0$aAlgebraic topology. 615 0$aManifolds (Mathematics) 615 0$aComplex manifolds. 615 0$aCategories (Mathematics) 615 0$aAlgebra, Homological. 615 14$aAlgebraic Topology. 615 24$aManifolds and Cell Complexes (incl. Diff.Topology). 615 24$aCategory Theory, Homological Algebra. 676 $a514.2 700 $aWeintraub$b Steven H$4aut$4http://id.loc.gov/vocabulary/relators/aut$059613 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910299968503321 996 $aFundamentals of algebraic topology$91410131 997 $aUNINA