LEADER 03705nam 22006255 450 001 9910299896803321 005 20200629183851.0 010 $a3-319-69059-0 024 7 $a10.1007/978-3-319-69059-9 035 $a(CKB)4100000001041451 035 $a(DE-He213)978-3-319-69059-9 035 $a(MiAaPQ)EBC5149408 035 $a(PPN)221247203 035 $a(EXLCZ)994100000001041451 100 $a20171115d2018 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAcute and Chronic Neural Stimulation via Mechano-Sensitive Ion Channels /$fby Andy Kah Ping Tay 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (XVII, 119 p. 33 illus., 32 illus. in color.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 $a3-319-69058-2 320 $aIncludes bibliographical references at the end of each chapters. 327 $aMicro- and Nano-Technologies to Probe Brain Mechanobiology -- Acute Neural Stimulation -- Chronic Neural Stimulation -- Phenotypic Selection of Magnetospirillum magneticum (AMB-1) Over-Producers using Magnetic Ratcheting -- Magnetic Microfluidic Separation for Estimating the Magnetic Contents of Magnetotactic Bacteria -- Outlook for Magnetic Neural Stimulation Techniques. . 330 $aThis book describes the tools, developed by the author, for perturbing endogenous mechano-sensitive ion channels for magneto-mechanical neuro-modulation. He explores the ways in which these tools compare against existing ones such as electricity, chemicals, optogenetics, and techniques like thermos/magneto-genetics. The author also reports on two platforms?magnetic ratcheting and magnetic microfluidics for directed evolution and high throughput culture of magnetotactic bacteria?that produce high quality magnetic nanoparticles for biomedical applications like neural stimulations. This thesis was submitted to and approved by the University of California, Los Angeles. Introduces technology for non-invasive control of neural activities that offer deep tissue penetration and controllable dosage; Examines the effects of biomechanical forces on cellular functions; Explores how to improve the reproducibility and uptake of magnetic tools for non-invasive neural modulation. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aBiomedical engineering 606 $aNanotechnology 606 $aNanoscience 606 $aNanoscience 606 $aNanostructures 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aNanotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/Z14000 606 $aNanoscale Science and Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/P25140 615 0$aBiomedical engineering. 615 0$aNanotechnology. 615 0$aNanoscience. 615 0$aNanoscience. 615 0$aNanostructures. 615 14$aBiomedical Engineering and Bioengineering. 615 24$aNanotechnology. 615 24$aNanoscale Science and Technology. 676 $a616.804645 700 $aTay$b Andy Kah Ping$4aut$4http://id.loc.gov/vocabulary/relators/aut$01065055 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910299896803321 996 $aAcute and Chronic Neural Stimulation via Mechano-Sensitive Ion Channels$92542810 997 $aUNINA