LEADER 04932nam 22007695 450 001 9910299853903321 005 20200701235428.0 010 $a1-4471-6599-3 024 7 $a10.1007/978-1-4471-6599-6 035 $a(CKB)3710000000261322 035 $a(EBL)1964789 035 $a(OCoLC)893564417 035 $a(SSID)ssj0001372493 035 $a(PQKBManifestationID)11978679 035 $a(PQKBTitleCode)TC0001372493 035 $a(PQKBWorkID)11304567 035 $a(PQKB)10706428 035 $a(DE-He213)978-1-4471-6599-6 035 $a(MiAaPQ)EBC1964789 035 $a(PPN)182094286 035 $a(EXLCZ)993710000000261322 100 $a20141010d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMultiscale Modeling in Biomechanics and Mechanobiology /$fedited by Suvranu De, Wonmuk Hwang, Ellen Kuhl 205 $a1st ed. 2015. 210 1$aLondon :$cSpringer London :$cImprint: Springer,$d2015. 215 $a1 online resource (287 p.) 300 $aDescription based upon print version of record. 311 $a1-4471-6598-5 320 $aIncludes bibliographical references at the end of each chapters. 327 $a1. Proteins: Ssp DnaE Intein -- 2. Protein Crystals: Molecular to Continuum Level Models based on Crystal Plasticity Theory -- 3. Molecular Motors: Cooperative Phenomena of Multiple Molecular Motors. ? 4. Biofilament dynamics: Line-to-rod-level Descriptions -- 5. Primary Cilia: Multi-Scale Structures that integrate Biomechanics and Mechanobiology. ? 6. Biological Scaffolding: Reduced-Order Network Models -- 7. Transport phenomena: Computational models for convective and diffusive transport in capillaries and tissue -- 8.Tendons and ligaments: Current state and future directions. ? 9. Arteries: Mechanics, Mechanobiology, and the Need for a New Class of Models -- 10. Mitral Valves: A computational framework. ? 11. Biological systems: Multiscale modeling based on Mixture Theory. 330 $aPresenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models.   Biomechanics involves the study of the interactions of physical forces with biological systems at all scales ? including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces ? bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines.   Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology. 606 $aMechanics 606 $aMechanics, Applied 606 $aBiomedical engineering 606 $aBiomathematics 606 $aBioinformatics 606 $aComputational biology 606 $aTheoretical and Applied Mechanics$3https://scigraph.springernature.com/ontologies/product-market-codes/T15001 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aMathematical and Computational Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/M31000 606 $aComputer Appl. in Life Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/L17004 615 0$aMechanics. 615 0$aMechanics, Applied. 615 0$aBiomedical engineering. 615 0$aBiomathematics. 615 0$aBioinformatics. 615 0$aComputational biology. 615 14$aTheoretical and Applied Mechanics. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aMathematical and Computational Biology. 615 24$aComputer Appl. in Life Sciences. 676 $a570.285 676 $a570285 676 $a610.28 676 $a620 702 $aDe$b Suvranu$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHwang$b Wonmuk$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKuhl$b Ellen$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910299853903321 996 $aMultiscale Modeling in Biomechanics and Mechanobiology$91465808 997 $aUNINA