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101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt
182   $cc
183   $acr
200 12$aA Guide to Numerical Modelling in Systems Biology /$fby Peter Deuflhard, Susanna Röblitz
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015.
215   $a1 online resource (X, 168 p. 42 illus., 33 illus. in color.)
225 1 $aTexts in Computational Science and Engineering,$x1611-0994 ;$v12
300   $aBibliographic Level Mode of Issuance: Monograph
311 08$a3-319-20058-5 
327   $aPreface -- Outline -- ODE Models for Systems Biological Networks -- Numerical Simulation of ODE Models -- Parameter Identification in ODE Models -- Appendix -- Software -- Index.
330   $aThis book is intended for students of computational systems biology with only a limited background in mathematics. Typical books on systems biology merely mention algorithmic approaches, but without offering a deeper understanding. On the other hand, mathematical books are typically unreadable for computational biologists. The authors of the present book have worked hard to fill this gap. The result is not a book on systems biology, but on computational methods in systems biology. This book originated from courses taught by the authors at Freie Universität Berlin. The guiding idea of the courses was to convey those mathematical insights that are indispensable for systems biology, teaching the necessary mathematical prerequisites by means of many illustrative examples and without any theorems. The three chapters cover the mathematical modelling of biochemical and physiological processes, numerical simulation of the dynamics of biological networks, and identification of model parameters by means of comparisons with real data. Throughout the text, the strengths and weaknesses of numerical algorithms with respect to various systems biological issues are discussed. Web addresses for downloading the corresponding software are also included.  .
410  0$aTexts in Computational Science and Engineering,$x1611-0994 ;$v12
606   $aDifferential equations
606   $aApplied mathematics
606   $aEngineering mathematics
606   $aBiomathematics
606   $aComputer simulation
606   $aPhysics
606   $aOrdinary Differential Equations$3https://scigraph.springernature.com/ontologies/product-market-codes/M12147
606   $aApplications of Mathematics$3https://scigraph.springernature.com/ontologies/product-market-codes/M13003
606   $aMathematical and Computational Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/M31000
606   $aSimulation and Modeling$3https://scigraph.springernature.com/ontologies/product-market-codes/I19000
606   $aNumerical and Computational Physics, Simulation$3https://scigraph.springernature.com/ontologies/product-market-codes/P19021
615  0$aDifferential equations.
615  0$aApplied mathematics.
615  0$aEngineering mathematics.
615  0$aBiomathematics.
615  0$aComputer simulation.
615  0$aPhysics.
615 14$aOrdinary Differential Equations.
615 24$aApplications of Mathematics.
615 24$aMathematical and Computational Biology.
615 24$aSimulation and Modeling.
615 24$aNumerical and Computational Physics, Simulation.
676   $a515.352
700   $aDeuflhard$b Peter$4aut$4http://id.loc.gov/vocabulary/relators/aut$067060
702   $aRo?blitz$b Susanna$4aut$4http://id.loc.gov/vocabulary/relators/aut
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910299787303321
996   $aA Guide to Numerical Modelling in Systems Biology$92504064
997   $aUNINA