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200 10$aOptimized Response-Adaptive Clinical Trials $eSequential Treatment Allocation Based on Markov Decision Problems /$fby Thomas Ondra
205   $a1st ed. 2015.
210  1$aWiesbaden :$cSpringer Fachmedien Wiesbaden :$cImprint: Springer Spektrum,$d2015.
215   $a1 online resource (112 p.)
225 1 $aBestMasters,$x2625-3615
300   $aDescription based upon print version of record.
311   $a3-658-08343-3 
320   $aIncludes bibliographical references.
327   $aIntroduction to Markov Decision Problems and Examples -- Finite and Infinite Horizon Markov Decision Problems -- Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration -- Designing Response Adaptive Clinical Trials with Markov Decision Problems.
330   $aTwo-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences. Contents Introduction to Markov Decision Problems and Examples Finite and Infinite Horizon Markov Decision Problems Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration Designing Response Adaptive Clinical Trials with Markov Decision Problems Target Groups Researchers and students in the fields of mathematics and statistics Professionals in the pharmaceutical industry< The Author Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.  .
410  0$aBestMasters,$x2625-3615
606   $aMathematics$xData processing
606   $aProbabilities
606   $aMathematical analysis
606   $aComputational Mathematics and Numerical Analysis
606   $aProbability Theory
606   $aAnalysis
615  0$aMathematics$xData processing.
615  0$aProbabilities.
615  0$aMathematical analysis.
615 14$aComputational Mathematics and Numerical Analysis.
615 24$aProbability Theory.
615 24$aAnalysis.
676   $a530.1
676   $a530.15
700   $aOndra$b Thomas$4aut$4http://id.loc.gov/vocabulary/relators/aut$0768291
906   $aBOOK
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996   $aOptimized Response-Adaptive Clinical Trials$91564830
997   $aUNINA