LEADER 01860nam 2200421Ia 450 001 996395899403316 005 20210104171417.0 035 $a(CKB)3810000000018035 035 $a(EEBO)2240871908 035 $a(OCoLC)ocn767619150e 035 $a(OCoLC)767619150 035 $a(EXLCZ)993810000000018035 100 $a20111206d1698 uy 0 101 0 $aeng 135 $aurbn||||a|bb| 200 10$aBy the Lords Justices General and General Governors of Ireland, a proclamation$b[electronic resource] $eWinchester, Gallway. Whereas the regiments commanded by the late Brigadeer William Wolsley, .. 210 $aDublin, $cPrinted by Andrew Crook, printer to the King's Most Excellent Majesty, on Cork-Hill, near Copper-Alley$d1698 215 $a1 sheet ([2] p.) $ccoat of arms 300 $aTitle from caption and opening lines of text. 300 $aSigned: H. May. 300 $aImprint from colophon. 300 $aAt end of text: Given at His Majesty's castle of Dublin, the 12th day of July, 1698. 300 $aConcerning arrears due to officers of disbanded regiments. 300 $aText printed chiefly in black letter. 300 $aImperfect: stained; print show-through with some loss of text. 300 $aReproduction of original in: National Library of Scotland--Crawford Collections. 330 $aeebo-0097 608 $aProclamations$zIreland$y17th century.$2rbgenr 608 $aBroadsides$zIreland$y17th century.$2rbgenr 701 $aBolton$b Charles Powlett$cDuke of,$f1661-1719.$01002986 701 $aGalway$b Henri de Massue$cEarl of,$f1648-1720.$01002500 701 $aMay$b H.$ffl. 1697.$01002501 801 0$bUMI 801 1$bUMI 906 $aBOOK 912 $a996395899403316 996 $aBy the Lords Justices General and General Governors of Ireland, a proclamation$92302544 997 $aUNISA LEADER 05959nam 22008295 450 001 9910299767003321 005 20250605201029.0 010 $a3-319-18539-X 024 7 $a10.1007/978-3-319-18539-2 035 $a(CKB)3710000000467523 035 $a(SSID)ssj0001558523 035 $a(PQKBManifestationID)16183692 035 $a(PQKBTitleCode)TC0001558523 035 $a(PQKBWorkID)14819058 035 $a(PQKB)10396498 035 $a(DE-He213)978-3-319-18539-2 035 $a(MiAaPQ)EBC6311422 035 $a(MiAaPQ)EBC5586421 035 $a(Au-PeEL)EBL5586421 035 $a(OCoLC)919463985 035 $a(PPN)188456899 035 $a(EXLCZ)993710000000467523 100 $a20150827d2015 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aFundamentals of clinical trials /$fby Lawrence M. Friedman, Curt D. Furberg, David L. DeMets, David M. Reboussin, Christopher B. Granger 205 $a5th ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (XXI, 550 p. 49 illus., 7 illus. in color.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a3-319-18538-1 327 $aIntroduction to Clinical Trials -- Ethical Issues -- What is the Question? -- Study Population -- Basic Study Design -- The Randomization Process -- Blinding -- Sample Size -- Baseline Assessment -- Recruitment of Study Participants -- Data Collection and Quality Control -- Assessment and Reporting of Harm -- Assessment of Health Related Quality of Life -- Participant Adherence -- Survival Analysis -- Monitoring Committee Structure & Function -- Statistical Methods Used in Interim Monitoring -- Issues in Data Analysis -- Closeout -- Reporting and Interpreting of Results -- Multicenter Trials -- Regulatory Issues. 330 $aThis is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. Most chapters have been revised considerably from the fourth edition. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing, and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan, and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. This book has been successfully used for teaching courses in clinical trial methodology. . 606 $aAssaigs clínics$2thub 606 $aStatistics 606 $aPublic health 606 $aEpidemiology 606 $aCancer$xResearch 606 $aOncology 606 $aStatistics for Life Sciences, Medicine, Health Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/S17030 606 $aPublic Health$3https://scigraph.springernature.com/ontologies/product-market-codes/H27002 606 $aEpidemiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H63000 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 608 $aLlibres electrònics$2thub 615 7$aAssaigs clínics 615 0$aStatistics. 615 0$aPublic health. 615 0$aEpidemiology. 615 0$aCancer$xResearch. 615 0$aOncology. 615 14$aStatistics for Life Sciences, Medicine, Health Sciences. 615 24$aPublic Health. 615 24$aEpidemiology. 615 24$aCancer Research. 615 24$aOncology. 676 $a610.724 700 $aFriedman$b Lawrence M$4aut$4http://id.loc.gov/vocabulary/relators/aut$033180 702 $aFurberg$b Curt D$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aDeMets$b David L$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aReboussin$b David M$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aGranger$b Christopher B$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910299767003321 996 $aFundamentals of Clinical Trials$92508612 997 $aUNINA