LEADER 04250nam 22007455 450 001 9910299748203321 005 20200702155922.0 010 $a3-319-07082-7 024 7 $a10.1007/978-3-319-07082-7 035 $a(CKB)3710000000118042 035 $a(EBL)1731155 035 $a(OCoLC)885122300 035 $a(SSID)ssj0001239411 035 $a(PQKBManifestationID)11720107 035 $a(PQKBTitleCode)TC0001239411 035 $a(PQKBWorkID)11185421 035 $a(PQKB)10919832 035 $a(MiAaPQ)EBC1731155 035 $a(DE-He213)978-3-319-07082-7 035 $a(PPN)178785504 035 $a(EXLCZ)993710000000118042 100 $a20140520d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDissecting Regulatory Interactions of RNA and Protein $eCombining Computation and High-throughput Experiments in Systems Biology /$fby Marvin Jens 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (115 p.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 300 $a"Doctoral Thesis accepted by Humboldt University of Berlin, Germany." 311 $a3-319-07081-9 320 $aIncludes bibliographical references at the end of each chapters. 327 $aIntroduction -- Computational analysis of PAR-CLIP data -- Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR -- Binding site occupancy with competition interactions in equilibrium -- Circular RNAs are a large class of animal RNAs with regulatory potency -- Discussion -- Methods. 330 $aThe work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions, and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists, and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution, and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aComputational intelligence 606 $aSystems biology 606 $aBiological systems 606 $aGene expression 606 $aBiochemistry 606 $aComputational Intelligence$3https://scigraph.springernature.com/ontologies/product-market-codes/T11014 606 $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/P27050 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 615 0$aComputational intelligence. 615 0$aSystems biology. 615 0$aBiological systems. 615 0$aGene expression. 615 0$aBiochemistry. 615 14$aComputational Intelligence. 615 24$aSystems Biology. 615 24$aGene Expression. 615 24$aBiochemistry, general. 676 $a574.873282 700 $aJens$b Marvin$4aut$4http://id.loc.gov/vocabulary/relators/aut$0860935 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910299748203321 996 $aDissecting Regulatory Interactions of RNA and Protein$91921300 997 $aUNINA