LEADER 00975cam0-22003491i-450- 001 990000469490403321 005 20050705113231.0 010 $a88-7688-217-0 035 $a000046949 035 $aFED01000046949 035 $a(Aleph)000046949FED01 035 $a000046949 100 $a20020821d1985----km-y0itay50------ba 101 0 $aita$cfre 102 $aIT 105 $ay-------001yy 200 1 $aProgrammare in C$fClaude Nowakowski$gtraduzione di Antonio Garavaglia, Alessandra Napoletano 210 $aMilano$cEPSI$cEditsi$d1985 215 $aVI, 128 p.$d21 cm 454 0$12001$aProgrammer en C 610 0 $aInformatica$aLinguaggi di programmazione 700 1$aNowakowski,$bClaude 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000469490403321 952 $aVII-B-38$b143$fMAS 952 $a10 P.T. 416$b739 DIS$fDINEL 952 $a110-E-38$b2460$fMA1 959 $aDINEL 959 $aMAS 959 $aMA1 997 $aUNINA LEADER 04212nam 22007935 450 001 9910299699303321 005 20200703135414.0 010 $a3-319-15606-3 024 7 $a10.1007/978-3-319-15606-4 035 $a(CKB)3710000000360323 035 $a(EBL)1998212 035 $a(OCoLC)904131860 035 $a(SSID)ssj0001452074 035 $a(PQKBManifestationID)11806905 035 $a(PQKBTitleCode)TC0001452074 035 $a(PQKBWorkID)11487831 035 $a(PQKB)10586291 035 $a(DE-He213)978-3-319-15606-4 035 $a(MiAaPQ)EBC1998212 035 $a(PPN)184495474 035 $a(EXLCZ)993710000000360323 100 $a20150225d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAnalysis of Deterministic Cyclic Gene Regulatory Network Models with Delays /$fby Mehmet Eren Ahsen, Hitay Özbay, Silviu-Iulian Niculescu 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Birkhäuser,$d2015. 215 $a1 online resource (104 p.) 225 1 $aSpringerBriefs in Control, Automation and Robotics,$x2192-6786 300 $aDescription based upon print version of record. 311 $a3-319-15605-5 320 $aIncludes bibliographical references and index. 327 $aPreface -- Introduction -- Basic Tools from Systems and Control Theory -- Functions with Negative Schwarzian Derivatives -- Deterministic ODE-Based Model with Time Delay -- Gene Regulatory Networks under Negative Feedback -- Gene Regulatory Networks under Positive Feedback -- Summary and Concluding Remarks -- References. 330 $aThis brief examines a deterministic, ODE-based model for gene regulatory networks (GRN) that incorporates nonlinearities and time-delayed feedback. An introductory chapter provides some insights into molecular biology and GRNs. The mathematical tools necessary for studying the GRN model are then reviewed, in particular Hill functions and Schwarzian derivatives. One chapter is devoted to the analysis of GRNs under negative feedback with time delays and a special case of a homogenous GRN is considered. Asymptotic stability analysis of GRNs under positive feedback is then considered in a separate chapter, in which conditions leading to bi-stability are derived. Graduate and advanced undergraduate students and researchers in control engineering, applied mathematics, systems biology and synthetic biology will find this brief to be a clear and concise introduction to the modeling and analysis of GRNs. 410 0$aSpringerBriefs in Control, Automation and Robotics,$x2192-6786 606 $aSystem theory 606 $aBiomathematics 606 $aGene expression 606 $aAutomatic control 606 $aRobotics 606 $aMechatronics 606 $aSystems Theory, Control$3https://scigraph.springernature.com/ontologies/product-market-codes/M13070 606 $aMathematical and Computational Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/M31000 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aControl, Robotics, Mechatronics$3https://scigraph.springernature.com/ontologies/product-market-codes/T19000 615 0$aSystem theory. 615 0$aBiomathematics. 615 0$aGene expression. 615 0$aAutomatic control. 615 0$aRobotics. 615 0$aMechatronics. 615 14$aSystems Theory, Control. 615 24$aMathematical and Computational Biology. 615 24$aGene Expression. 615 24$aControl, Robotics, Mechatronics. 676 $a576.5 700 $aAhsen$b Mehmet Eren$4aut$4http://id.loc.gov/vocabulary/relators/aut$0720884 702 $aÖzbay$b Hitay$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aNiculescu$b Silviu-Iulian$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910299699303321 996 $aAnalysis of Deterministic Cyclic Gene Regulatory Network Models with Delays$92527372 997 $aUNINA