LEADER 05345nam 22007575 450 001 9910299669303321 005 20200707003337.0 010 $a3-319-09336-3 024 7 $a10.1007/978-3-319-09336-9 035 $a(CKB)3710000000262093 035 $a(EBL)1968271 035 $a(OCoLC)907304637 035 $a(SSID)ssj0001372487 035 $a(PQKBManifestationID)11881963 035 $a(PQKBTitleCode)TC0001372487 035 $a(PQKBWorkID)11304221 035 $a(PQKB)10969952 035 $a(DE-He213)978-3-319-09336-9 035 $a(MiAaPQ)EBC1968271 035 $a(PPN)182100219 035 $a(EXLCZ)993710000000262093 100 $a20141018d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Mechanobiology of Obesity and Related Diseases$b[electronic resource] /$fedited by Amit Gefen, Dafna Benayahu 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (298 p.) 225 1 $aStudies in Mechanobiology, Tissue Engineering and Biomaterials,$x1868-2006 ;$v16 300 $aDescription based upon print version of record. 311 $a3-319-09335-5 320 $aIncludes bibliographical references and index. 327 $aMechanical behavior and properties of adipose tissue -- Mathematical models of adipose tissue dynamics -- Mechanical stretching and signaling pathways in adipogenesis- Role of mechanical stimulations in directing mesenchymal stem cell adipogenesis -- The vicious cycle of estrogen consumption and obesity: The role of mechanotransduction -- Extracellular matrix remodeling and mechanical stresses as modulators of adipose tissue metabolism and inflammation -- The Impact of Obesity and Weight Loss on Gait in Adults -- Excessive Weight Bearing Compromises Foot Structure and Function across the Lifespan -- Obesity, Osteoarthritis and Aging: The Biomechanical Links -- Impaired neutrophil mechanoregulation by fluid flow: A potential contributing factor for microvascular dysfunction in obesity -- Mechanotransduction and the myogenic response in diabetes -- Role of adipose cells in tumor microenvironment. 330 $aThis volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors. 410 0$aStudies in Mechanobiology, Tissue Engineering and Biomaterials,$x1868-2006 ;$v16 606 $aBiomedical engineering 606 $aCell physiology 606 $aBiophysics 606 $aBiological physics 606 $aBiomaterials 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 606 $aBiomaterials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z13000 615 0$aBiomedical engineering. 615 0$aCell physiology. 615 0$aBiophysics. 615 0$aBiological physics. 615 0$aBiomaterials. 615 14$aBiomedical Engineering and Bioengineering. 615 24$aCell Physiology. 615 24$aBiological and Medical Physics, Biophysics. 615 24$aBiomaterials. 676 $a571.4 676 $a571.6 676 $a610.28 676 $a620 702 $aGefen$b Amit$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBenayahu$b Dafna$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910299669303321 996 $aMechanobiology of Obesity and Related Diseases$91413046 997 $aUNINA