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035   $a(DE-He213)978-4-431-56514-7
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100   $a20180110d2018      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aBone Adaptation $eIn Silico Approach /$fby Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
205   $a1st ed. 2018.
210  1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2018.
215   $a1 online resource (XIV, 209 p. 93 illus., 24 illus. in color.) 
225 1 $aFrontiers of Biomechanics,$x2199-8515 ;$v2
311   $a4-431-56512-4 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aOverview: In Silico Approaches to Understand Bone Adaptation -- Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus -- Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula -- Estimation of Bone Permeability for Poroelastic Analysis -- Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes -- Effects of Local Bending Load on Trabecular Bone Adaptation -- Cancellous Bone Adaptation Predicted by Remodeling Simulations -- Trabecular Surface Remodeling toward Uniform Local Stress State -- Spatial and Temporal Regulation of Cancellous Bone Structure by Trabecular Surface Remodeling -- Comparison of Mechanical Quantities as Bone Remodeling Stimuli -- Trabecular Surface Remodeling Simulation of Cancellous Bone Using Image-Based Voxel Finite Element Models -- Functional Adaptation of Cancellous Bone in Human Proximal Femur -- 3D Trabecular Remodeling in Human Proximal Femur: Approach to Understanding Wolff?s Law -- Trabecular Structural Changes in a Vertebral Body with a Fixation Screw.
330   $aThis book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.
410  0$aFrontiers of Biomechanics,$x2199-8515 ;$v2
606   $aBiomedical engineering
606   $aOrthopedics
606   $aBiomathematics
606   $aBiophysics
606   $aBiophysics
606   $aRegenerative medicine
606   $aTissue engineering
606   $aComputer simulation
606   $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X
606   $aOrthopedics$3https://scigraph.springernature.com/ontologies/product-market-codes/H45000
606   $aPhysiological, Cellular and Medical Topics$3https://scigraph.springernature.com/ontologies/product-market-codes/M31020
606   $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008
606   $aRegenerative Medicine/Tissue Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/L16080
606   $aSimulation and Modeling$3https://scigraph.springernature.com/ontologies/product-market-codes/I19000
615  0$aBiomedical engineering.
615  0$aOrthopedics.
615  0$aBiomathematics.
615  0$aBiophysics.
615  0$aBiophysics.
615  0$aRegenerative medicine.
615  0$aTissue engineering.
615  0$aComputer simulation.
615 14$aBiomedical Engineering and Bioengineering.
615 24$aOrthopedics.
615 24$aPhysiological, Cellular and Medical Topics.
615 24$aBiological and Medical Physics, Biophysics.
615 24$aRegenerative Medicine/Tissue Engineering.
615 24$aSimulation and Modeling.
676   $a610.28
700   $aKameo$b Yoshitaka$4aut$4http://id.loc.gov/vocabulary/relators/aut$01063483
702   $aTsubota$b Ken-ichi$4aut$4http://id.loc.gov/vocabulary/relators/aut
702   $aAdachi$b Taiji$4aut$4http://id.loc.gov/vocabulary/relators/aut
906   $aBOOK
912   $a9910299582103321
996   $aBone Adaptation$92532672
997   $aUNINA