LEADER 02941oam 2200517 450 001 9910299494803321 005 20190911103512.0 010 $a1-4614-9429-X 024 7 $a10.1007/978-1-4614-9429-4 035 $a(OCoLC)865009747 035 $a(MiFhGG)GVRL6UWN 035 $a(EXLCZ)993710000000057259 100 $a20131021d2014 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 10$aLogic synthesis for genetic diseases $emodeling disease behavior using Boolean networks /$fPey-Chang Kent Lin, Sunil P. Khatri 205 $a1st ed. 2014. 210 1$aNew York :$cSpringer,$d2014. 215 $a1 online resource (xxi, 100 pages) $cillustrations (some color) 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a1-4614-9428-1 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Part I Inference of Gene Regulatory Networks -- Predictor Set Inference using SAT -- Determining Gene Function in Boolean Networks using SAT -- Predictor Ranking using Modified Zhegalkin Functions -- Part II Intervention of Gene Regulatory Networks -- ATPG for Cancer Therapy -- Summary and Future Work. 330 $aThis book brings to bear a body of logic synthesis techniques, in order to contribute to the analysis and control of Boolean Networks (BN) for modeling genetic diseases such as cancer. The authors provide several VLSI logic techniques to model the genetic disease behavior as a BN, with powerful implicit enumeration techniques. Coverage also includes techniques from VLSI testing to control a faulty BN, transforming its behavior to a healthy BN, potentially aiding in efforts to find the best candidates for treatment of genetic diseases.    ? Discusses a new application for logic synthesis, which enables the use of Boolean Networks to model the behavior of genetic-based diseases; ? Demonstrates how techniques such as Boolean Satisfiability (SAT) and Automatic Test Pattern Generation (ATPG) can be applied in the context of genetics; ? Provides content that appeals to researchers in genetics and logic synthesis and enables readers to make the connection between genetic diseases and logic techniques in a clear, unambiguous manner. 606 $aGene regulatory networks 606 $aGenetic disorders 606 $aMedical genetics 615 0$aGene regulatory networks. 615 0$aGenetic disorders. 615 0$aMedical genetics. 676 $a570285 676 $a610.28 676 $a616.042011 676 $a620 700 $aLin$b Pey-Chang Kent$4aut$4http://id.loc.gov/vocabulary/relators/aut$0999565 702 $aKhatri$b Sunil P.$f1965- 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910299494803321 996 $aLogic Synthesis for Genetic Diseases$92294311 997 $aUNINA