LEADER 05431nam 22007575 450 001 9910298654803321 005 20200704030618.0 010 $a1-4939-1998-9 024 7 $a10.1007/978-1-4939-1998-7 035 $a(CKB)3710000000306012 035 $a(SSID)ssj0001386446 035 $a(PQKBManifestationID)11817451 035 $a(PQKBTitleCode)TC0001386446 035 $a(PQKBWorkID)11374503 035 $a(PQKB)10017055 035 $a(DE-He213)978-1-4939-1998-7 035 $a(MiAaPQ)EBC6311197 035 $a(MiAaPQ)EBC5595699 035 $a(Au-PeEL)EBL5595699 035 $a(OCoLC)899249138 035 $a(PPN)18308909X 035 $a(EXLCZ)993710000000306012 100 $a20141122d2014 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aDrug Delivery $eMaterials Design and Clinical Perspective /$fby Eric P. Holowka, Sujata K. Bhatia 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (XVII, 355 p. 260 illus., 36 illus. in color.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a1-4939-1997-0 327 $aIntroduction -- Controlled Release Systems -- Thin Film Materials -- Self-Microemulsifying Materials -- Targeted Materials -- Hydrogel Materials -- Smart Drug Delivery Systems -- Conclusion. 330 $aCurrent pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on ?Engineering Concepts? reviews the relevant fundamental principles that guide rational design. The following section on ?Materials Design? discusses how the design process applies engineering concepts for use in physiological systems. A third section on ?Implementation? discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on ?Clinical Applications? which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. ·         Provides a comprehensive description of drug delivery systems from a materials perspective ·         Includes a wide-ranging discussion of clinical applications of drug delivery systems ·         Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. ·         Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type. 606 $aBiomaterials 606 $aBiomedical engineering 606 $aPharmacology 606 $aPolymers   606 $aPharmacotherapy 606 $aBiomaterials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z13000 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aPolymer Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/C22008 606 $aPharmacotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H69000 615 0$aBiomaterials. 615 0$aBiomedical engineering. 615 0$aPharmacology. 615 0$aPolymers  . 615 0$aPharmacotherapy. 615 14$aBiomaterials. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aPharmacology/Toxicology. 615 24$aPolymer Sciences. 615 24$aPharmacotherapy. 676 $a610.28 700 $aHolowka$b Eric P$4aut$4http://id.loc.gov/vocabulary/relators/aut$01059165 702 $aBhatia$b Sujata K$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298654803321 996 $aDrug Delivery$92504457 997 $aUNINA