LEADER 04395oam 2200505 450 001 9910298649503321 005 20190911103512.0 010 $a1-4614-8999-7 024 7 $a10.1007/978-1-4614-8999-3 035 $a(OCoLC)864890585 035 $a(MiFhGG)GVRL6VNX 035 $a(EXLCZ)993710000000057106 100 $a20130927d2014 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 00$aMetal-on-metal bearings $ea clinical practicum /$fLynne C. Jones, A. Seth Greenwald, Warren O. Haggard, editors 205 $a1st ed. 2014. 210 1$aNew York :$cSpringer,$d2014. 215 $a1 online resource (x, 200 pages) $cillustrations (some color) 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a1-4614-8998-9 320 $aIncludes bibliographical references and index. 327 $aPreface -- Part I: Introduction -- Chapter 1: Overview of Metal-on-Metal Implants -- Chapter 2: Bearing Surfaces for Joint Replacement: New Materials or New Problems? -- Part II: Clinical -- Chapter 3: Outcome Studies for Metal-on-Metal Bearings: What Evidence-Based Medicine Tells Us -- Chapter 4: Metal Reactivity: Its Influence on Primary and Revision Outcomes -- Chapter 5: Are metal ion levels a trigger for surgical intervention? -- Chapter 6: Metal Sensitivity: Is it possible to Determine Clinically? -- Part III: Biology -- Chapter 7: Wound healing, chronic inflammation, and immune responses -- Chapter 8: Benign Responses to Orthopaedic Implants: Really? -- Chapter 9: What does the Histology Tell Us? -- Part IV: Biomechanics -- Chapter 10: Why metal-on-metal -what laboratory tests have shown us -- Chapter 11: What do the Retrievals really tell us? -- Future Directions.- Index. 330 $aThis book addresses the background and significance of the factors potentially influencing the clinical and biological outcomes of metal-on-metal hip implants. Metal-on-metal bearings were introduced and evaluated as an alternative to other bearing couples, particularly metal-on-polyethylene, due to their enhanced wear resistance as determined in laboratory testing. Initially, reports of short-term clinical outcomes were favorable and an increasing number of metal-on-metal prostheses were implanted. Subsequently, isolated case findings describing adverse tissue responses around the articulation became the harbinger of an increasing number of reports describing pseudotumors and other significant lymphocytic-based responses associated with metal-on-metal prostheses. Questions have been raised as to whether this is an implant, design, or patient-specific response. The reasons why some patients have a negative biological response and pathology while others do not remain to be determined, but tens of thousands of patients in the US,  the UK, and around the world are considered to be at risk. Leading researchers and clinicians describe the issues related to the nature of the biological and pathological responses and the protocols that should be followed to determine if an adverse response is occurring. This book is essential reading for researchers, engineers, and orthopaedic surgeons who are involved in the design, evaluation, and implantation of metal-on-metal prostheses. Presents an historical overview of the use of metal-on-metal articulations Collects for the first time the information necessary to assess clinically and biologically relevant patient outcomes Addresses the practical questions that are being raised by surgeons, researchers, and engineers Features contributions by acknowledged leaders in their fields Describes what the clinician needs to know in order to practice evidence-based medicine Projects directions for clinical, biological, and biomechanical research efforts. 606 $aArtificial joints$xBearings$xMaterials 606 $aBiomedical materials 615 0$aArtificial joints$xBearings$xMaterials. 615 0$aBiomedical materials. 676 $a610.28 676 $a611.01816 676 $a616.7 676 $a617.5810592 702 $aJones$b Lynne C. 702 $aGreenwald$b A. Seth 702 $aHaggard$b Warren O. 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910298649503321 996 $aMetal-on-Metal Bearings$92544236 997 $aUNINA