LEADER 04343nam 22006855 450 001 9910298645503321 005 20231116222127.0 010 $a3-319-08675-8 024 7 $a10.1007/978-3-319-08675-0 035 $a(CKB)3710000000281325 035 $a(EBL)1968130 035 $a(OCoLC)908088800 035 $a(SSID)ssj0001386384 035 $a(PQKBManifestationID)11896945 035 $a(PQKBTitleCode)TC0001386384 035 $a(PQKBWorkID)11374134 035 $a(PQKB)11337466 035 $a(MiAaPQ)EBC1968130 035 $a(DE-He213)978-3-319-08675-0 035 $a(PPN)183096940 035 $a(EXLCZ)993710000000281325 100 $a20141114d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCarbohydrates as Drugs$b[electronic resource] /$fedited by Peter H. Seeberger, Christoph Rademacher 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (242 p.) 225 1 $aTopics in Medicinal Chemistry,$x1862-2461 ;$v12 300 $aDescription based upon print version of record. 311 $a3-319-08674-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCarbohydrate-Based Synthetic Chemistry in the Context of Drug Design -- Iminosugars: Therapeutic Applications and Synthetic Considerations -- Computational Docking as a Tool for the Rational Design of Carbohydrate-Based Drugs -- Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapagliflozin for the Treatment of Type 2 Diabetes -- Design, Synthesis, and Applications of Galectin Modulators in Human Health -- Discovery and Application of FimH Antagonists -- Carbohydrate-Based Anti-Virulence Compounds Against Chronic Pseudomonas aeruginosa Infections with a Focus on Small Molecules -- The Evolution of a Glycoconjugate Vaccine for Candida albicans. 330 $aMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. 410 0$aTopics in Medicinal Chemistry,$x1862-2461 ;$v12 606 $aMedicinal chemistry 606 $aCarbohydrates 606 $aMolecular biology 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aCarbohydrate Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19030 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aMedicinal chemistry. 615 0$aCarbohydrates. 615 0$aMolecular biology. 615 14$aMedicinal Chemistry. 615 24$aCarbohydrate Chemistry. 615 24$aMolecular Medicine. 676 $a615.3 702 $aSeeberger$b Peter H.$f1966-$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRademacher$b Christoph$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298645503321 996 $aCarbohydrates as Drugs$92515820 997 $aUNINA