LEADER 03355nam 22006495 450 001 9910298642003321 005 20200704114857.0 010 $a3-642-54304-9 024 7 $a10.1007/978-3-642-54304-3 035 $a(CKB)3710000000089218 035 $a(EBL)1783256 035 $a(OCoLC)872577832 035 $a(SSID)ssj0001186498 035 $a(PQKBManifestationID)11813505 035 $a(PQKBTitleCode)TC0001186498 035 $a(PQKBWorkID)11240261 035 $a(PQKB)11574015 035 $a(MiAaPQ)EBC1783256 035 $a(DE-He213)978-3-642-54304-3 035 $a(PPN)176751866 035 $a(EXLCZ)993710000000089218 100 $a20140226d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTotal Synthesis of (±)-Maoecrystal V /$fby Jianxian Gong 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (146 p.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 300 $aDescription based upon print version of record. 311 $a3-642-54303-0 320 $aInclues bibliographical references. 327 $aResearch Background for Natural Product Maoecrystal V and Its Family -- The Model Study of Natural Product Maoecrystal V -- The total synthesis study of Maoecrystal V -- Summary. 330 $aIn this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereoselective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aOrganic chemistry 606 $aMedicinal chemistry 606 $aCatalysis 606 $aOrganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19007 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aCatalysis$3https://scigraph.springernature.com/ontologies/product-market-codes/C29000 615 0$aOrganic chemistry. 615 0$aMedicinal chemistry. 615 0$aCatalysis. 615 14$aOrganic Chemistry. 615 24$aMedicinal Chemistry. 615 24$aCatalysis. 676 $a547.7 676 $a547.70459 700 $aGong$b Jianxian$4aut$4http://id.loc.gov/vocabulary/relators/aut$01060636 906 $aBOOK 912 $a9910298642003321 996 $aTotal Synthesis of (±)-Maoecrystal V$92514710 997 $aUNINA