LEADER 04723nam 22007215 450 001 9910298636303321 005 20231020234011.0 010 $a3-662-44431-3 024 7 $a10.1007/978-3-662-44431-3 035 $a(CKB)3710000000277531 035 $a(EBL)1966040 035 $a(SSID)ssj0001386459 035 $a(PQKBManifestationID)11759674 035 $a(PQKBTitleCode)TC0001386459 035 $a(PQKBWorkID)11374308 035 $a(PQKB)11731630 035 $a(MiAaPQ)EBC1966040 035 $a(DE-He213)978-3-662-44431-3 035 $a(PPN)183088271 035 $a(EXLCZ)993710000000277531 100 $a20141104d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEnvironmentally Friendly Alkylphosphonate Herbicides /$fby Hong-Wu He, Hao Peng, Xiao-Song Tan 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (471 p.) 300 $aDescription based upon print version of record. 311 $a3-662-44430-5 320 $aIncludes bibliographical references and index. 327 $aOverview -- Alkylphosphonates -- Salts of Alkylphosphonates -- Alkylphosphinates -- Cyclic Phosphonates and Caged Bicyclic Phosphates -- Optically Active Alkylphosphonates -- Biochemistry and Mechanism of Alkylphosphonates as PDHc Inhibitors -- Evaluation and Application of Clacyfos and HWS -- General Methodology. 330 $aThis book presents essential research on a class of environmentally friendly alkylphosphonate herbicides. This class of herbicides acted as a competitive inhibitor of the pyruvate dehydrogenase complex (PDHc) to control weeds. The bioreasoning and systematic approach, from basic research to field tests of candidate compounds, are introduced. The basic research covers the molecular design, chemical synthesis, biological activities evaluation, structure-activity relationship analysis and structural optimization. Subsequently, the book reviews the biochemistry of PDHc inhibitors, the selectivity between mammals and plants, and the mechanism of herbicidal activity of novel alkylphosphonates as selective PDHc inhibitors. Field trials for selected alkylphosphonate candidates as herbicides are also included. This book provides a sound basis for the rational design and development of novel herbicides as effective PDHc inhibitors with good enzyme-selective inhibition of plant PDHc between mammals and plants. These studies take full advantages of the low toxicity and low residual impact of selective PHDc inhibitors to design an effective and environmentally friendly herbicide. This book is based on twenty years of research on alkylphosphonates and phosphorus-containing PDHc inhibitors, and demonstrates how to develop these PDHc inhibitors as an effective and ?green? herbicide candidate.   Hong-Wu He, PhD, is a Professor at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, and Director of the Institute of Pesticide Chemistry, College of Chemistry, Central China Normal University, China. Hao Peng, PhD, and Xiao-Song Tan are both Associate Professors at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, College of Chemistry, Central China Normal University, China. 606 $aOrganic chemistry 606 $aPlant biochemistry 606 $aEnvironmental chemistry 606 $aAgriculture 606 $aOrganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19007 606 $aPlant Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14021 606 $aEnvironmental Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/U15000 606 $aAgriculture$3https://scigraph.springernature.com/ontologies/product-market-codes/L11006 615 0$aOrganic chemistry. 615 0$aPlant biochemistry. 615 0$aEnvironmental chemistry. 615 0$aAgriculture. 615 14$aOrganic Chemistry. 615 24$aPlant Biochemistry. 615 24$aEnvironmental Chemistry. 615 24$aAgriculture. 676 $a54 676 $a547 676 $a572572 676 $a577.14 676 $a630 700 $aHe$b Hong-Wu$4aut$4http://id.loc.gov/vocabulary/relators/aut$01061943 702 $aPeng$b Hao$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aTan$b Xiao-Song$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910298636303321 996 $aEnvironmentally Friendly Alkylphosphonate Herbicides$92521553 997 $aUNINA