LEADER 05325nam 22007695 450 001 9910298628803321 005 20200706161745.0 010 $a3-319-16145-8 024 7 $a10.1007/978-3-319-16145-7 035 $a(CKB)3710000000394667 035 $a(EBL)2094491 035 $a(SSID)ssj0001500937 035 $a(PQKBManifestationID)11874365 035 $a(PQKBTitleCode)TC0001500937 035 $a(PQKBWorkID)11523025 035 $a(PQKB)10462799 035 $a(DE-He213)978-3-319-16145-7 035 $a(MiAaPQ)EBC3109277 035 $a(MiAaPQ)EBC2094491 035 $a(Au-PeEL)EBL2094491 035 $a(OCoLC)906804051 035 $a(PPN)185485758 035 $a(EXLCZ)993710000000394667 100 $a20150406d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMathematical Modeling and Scale-Up of Liquid Chromatography $eWith Application Examples /$fby Tingyue Gu 205 $a2nd ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (214 p.) 300 $aDescription based upon print version of record. 311 $a3-319-16144-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction -- Literature Review -- General Multicomponent Rate Models for Column Liquid Chromatography -- Parameter Estimation -- Mass Transfer Effects in Liquid Chromatography Simulation -- Interference Effects in Multicomponent Chromatography -- System Peaks in Multicomponent Elution -- Modeling and Scale-up of Size Exclusion Chromatography -- Modeling of LC with cored beads -- Modeling of Slow Kinetics and Affinity Chromatography -- Multicomponent Adsorption with Uneven Saturation Capacities -- Modeling of Multicomponent Gradient Elution -- Modeling of Ion-Exchange Chromatography -- Multicomponents Radial Flow Chromatography. 330 $aTingyue Gu's second edition provides a comprehensive set of nonlinear multicomponent liquid chromatography (LC) models for various forms of LC, such as adsorption, size exclusion, ion-exchange, reversed-phase, affinity, isocratic/gradient elution and axial/radial flow LC. Much has advanced since the first edition of this book and the author's software, described here, is now used for teaching and research in 32 different countries. This book comes together with a complete software package with graphical user interface for personal computers, offered free for academic applications. Additionally, this book provides detailed methods for parameter estimation of mass transfer coefficients, bed voidage, particle porosity and isotherms. The author gives examples of how to use the software for predictions and scale-up. In contrast to the first edition, authors do not need to deal with complicated math. Instead, they focus on how to obtain a few parameters for simulation and how to compare simulation results with experimental data. After reading the detailed descriptions in the book, a reader is able to use the simulation software to investigate chromatographic behavior without doing actual experiments. This book is aimed at readers who are interested in learning about LC behaviors and at those who want to scale up LC for preparative- and large-scale applications. Both academic personnel and industrial practitioners can benefit from the use of the book. This new edition includes: - New models and software for pellicular (cored) beads in liquid chromatography - Introduction of user-friendly software (with graphical user interface) - Detailed descriptions on how to use the software - Step-by-step instructions on parameter estimation for the models - New mass-transfer correlations for parameter estimation - Experimental methods for parameter estimation - Several actual examples using the model for product development and scale-up - Updated literature review. 606 $aChromatography 606 $aChemoinformatics 606 $aChemical engineering 606 $aBiochemical engineering 606 $aChromatography$3https://scigraph.springernature.com/ontologies/product-market-codes/C11030 606 $aComputer Applications in Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C13009 606 $aIndustrial Chemistry/Chemical Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C27000 606 $aBiochemical Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C12029 615 0$aChromatography. 615 0$aChemoinformatics. 615 0$aChemical engineering. 615 0$aBiochemical engineering. 615 14$aChromatography. 615 24$aComputer Applications in Chemistry. 615 24$aIndustrial Chemistry/Chemical Engineering. 615 24$aBiochemical Engineering. 676 $a54 676 $a541.0285 676 $a543.8 676 $a660 676 $a660.63 700 $aGu$b Tingyue$4aut$4http://id.loc.gov/vocabulary/relators/aut$0740223 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298628803321 996 $aMathematical Modeling and Scale-Up of Liquid Chromatography$92225289 997 $aUNINA