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100   $a20151216d2015      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
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183   $acr
200 10$aArtificially Controllable Nanodevices Constructed by DNA Origami Technology$b[electronic resource] $ePhotofunctionalization and Single-Molecule Analysis /$fby Yangyang Yang
205   $a1st ed. 2015.
210  1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2015.
215   $a1 online resource (82 p.)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $aDescription based upon print version of record.
311   $a4-431-55768-7 
320   $aIncludes bibliographical references.
327   $aIntroduction -- Direct observation of single hybridization and dissociation of photoresponsive oligonucleotides in the designed DNA nanostructure -- Direct observation of logic-gated dual-switching behaviors inducing the state transition in a DNA nanostructure -- Multi-directionally photo-controllable DNA nanostructure assembling reversibly in programmed patterns -- Arrangement of gold nanoparticles onto a slit-type DNA nanostructure in various patterns.
330   $aIn this book, the author deals mainly with two topics: (1) single-molecule visualization of switching behaviors in the DNA nanoframe system utilizing different kinds of molecular switches through the use of high-speed atomic force microscope (AFM); (2) construction of photocontrollable DNA nanostructures in programmed patterns and direct visualization of the dynamic assembling process. Here, high-speed AFM was employed to observe the dynamic movements of single molecules. Compared to a traditional single-molecule analysis method, such as fluorescence spectroscopy or electron microscopy, high-speed AFM makes possible the real-time observation of molecule behaviors. DNA nanostructures were designed and assembled as scaffolds to incorporate interested biomolecules. The observations were carried out under robust conditions without complicated pretreatment. Moreover, the photoresponsive molecules were successfully assembled into around 100 nm-sized DNA nanostructures. The assembly/disassembly of nanostructures can be regulated reversibly by photoirradiation. This book explains how DNA origami has gradually become a useful tool for the investigation of biochemical interactions in defined nanospace. It also shows the possibility of DNA nanostructures acting as nanodevices for application in biological systems, serving as a good introduction to basic DNA nanotechnology.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aNanochemistry
606   $aNanotechnology
606   $aMicroscopy
606   $aSpectroscopy
606   $aNanochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C33000
606   $aNanotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/Z14000
606   $aBiological Microscopy$3https://scigraph.springernature.com/ontologies/product-market-codes/L26000
606   $aSpectroscopy and Microscopy$3https://scigraph.springernature.com/ontologies/product-market-codes/P31090
615  0$aNanochemistry.
615  0$aNanotechnology.
615  0$aMicroscopy.
615  0$aSpectroscopy.
615 14$aNanochemistry.
615 24$aNanotechnology.
615 24$aBiological Microscopy.
615 24$aSpectroscopy and Microscopy.
676   $a540
700   $aYang$b Yangyang$4aut$4http://id.loc.gov/vocabulary/relators/aut$0993467
906   $aBOOK
912   $a9910298623603321
996   $aArtificially Controllable Nanodevices Constructed by DNA Origami Technology$92274727
997   $aUNINA