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010   $a3-319-18753-8
024 7 $a10.1007/978-3-319-18753-2
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035   $a(DE-He213)978-3-319-18753-2
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100   $a20150518d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aHyperbranched Polydendrons $eA New Macromolecular Architecture /$fby Fiona L. Hatton
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015.
215   $a1 online resource (279 p.)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $a"Doctoral Thesis accepted by the University of Liverpool, UK"--T.p.
311   $a3-319-18752-X 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aIntroduction -- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles -- Hyp-Polydendrons; studies of nanoprecipitation behavior -- Conclusions and Future work -- Experimental.
330   $aThis thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles ? a research goal that is currently being pursued by several groups around the globe.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aPharmaceutical chemistry
606   $aPolymers
606   $aNanochemistry
606   $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000
606   $aPolymer Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/C22008
606   $aNanochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C33000
615  0$aPharmaceutical chemistry.
615  0$aPolymers.
615  0$aNanochemistry.
615 14$aMedicinal Chemistry.
615 24$aPolymer Sciences.
615 24$aNanochemistry.
676   $a668.92
700   $aHatton$b Fiona L$4aut$4http://id.loc.gov/vocabulary/relators/aut$0994058
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910298614403321
996   $aHyperbranched Polydendrons$92276631
997   $aUNINA