LEADER 01271nam0 22003131i 450 001 UON00385504 005 20231205104548.522 010 $a05-7104-829-3 100 $a20101103d1976 |0itac50 ba 101 $aeng 102 $aGB 105 $a|||| ||||| 200 1 $aˆAn ‰agricultural atlas of England and Wales$fby J.T. Coppock$gwith a foreword by Frank Engeldow$gtechnical appendix J. McG. Hotson 210 $aLondon$cFaber and Faber LTD$d1976 215 $a267 p.$cill.$d25 cm. 316 $aex inv. SC 4033$5IT-UONSI ATLVI/045 Bis 620 $aGB$dLondon$3UONL003044 686 $aATL VI$cATLANTI - EUROPA$2A 700 1$aCOPPOCK$bJ. T.$3UONV108555$0643428 702 1$aENGELDOW$bFrank$3UONV017986 702 1$aHOTSON$bMcG.$3UONV017988 712 $aFaber and Faber$3UONV246465$4650 790 1$aCOPPOCK, John Terence$zCOPPOCK, J. T.$3UONV218836 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00385504 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI ATL VI 045 Bis $eSI G 4818 7 045 Bis ex inv. SC 4033$sBuono 996 $aAgricultural atlas of England and Wales$91200411 997 $aUNIOR LEADER 03940nam 22006735 450 001 9910298614403321 005 20200705061403.0 010 $a3-319-18753-8 024 7 $a10.1007/978-3-319-18753-2 035 $a(CKB)3710000000414315 035 $a(EBL)2120637 035 $a(OCoLC)909368005 035 $a(SSID)ssj0001500931 035 $a(PQKBManifestationID)11918265 035 $a(PQKBTitleCode)TC0001500931 035 $a(PQKBWorkID)11522867 035 $a(PQKB)11215102 035 $a(DE-He213)978-3-319-18753-2 035 $a(MiAaPQ)EBC2120637 035 $a(PPN)18603153X 035 $a(EXLCZ)993710000000414315 100 $a20150518d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHyperbranched Polydendrons $eA New Macromolecular Architecture /$fby Fiona L. Hatton 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (279 p.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 300 $a"Doctoral Thesis accepted by the University of Liverpool, UK"--T.p. 311 $a3-319-18752-X 320 $aIncludes bibliographical references at the end of each chapters. 327 $aIntroduction -- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles -- Hyp-Polydendrons; studies of nanoprecipitation behavior -- Conclusions and Future work -- Experimental. 330 $aThis thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles ? a research goal that is currently being pursued by several groups around the globe. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aPharmaceutical chemistry 606 $aPolymers 606 $aNanochemistry 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aPolymer Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/C22008 606 $aNanochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C33000 615 0$aPharmaceutical chemistry. 615 0$aPolymers. 615 0$aNanochemistry. 615 14$aMedicinal Chemistry. 615 24$aPolymer Sciences. 615 24$aNanochemistry. 676 $a668.92 700 $aHatton$b Fiona L$4aut$4http://id.loc.gov/vocabulary/relators/aut$0994058 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298614403321 996 $aHyperbranched Polydendrons$92276631 997 $aUNINA