LEADER 04007nam 22006615 450 001 9910298609303321 005 20200703022743.0 010 $a3-319-19755-X 024 7 $a10.1007/978-3-319-19755-5 035 $a(CKB)3710000000436764 035 $a(EBL)2097289 035 $a(SSID)ssj0001525106 035 $a(PQKBManifestationID)11869900 035 $a(PQKBTitleCode)TC0001525106 035 $a(PQKBWorkID)11485253 035 $a(PQKB)11573188 035 $a(DE-He213)978-3-319-19755-5 035 $a(MiAaPQ)EBC2097289 035 $a(PPN)186400608 035 $a(EXLCZ)993710000000436764 100 $a20150623d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Smoothened Receptor in Cancer and Regenerative Medicine /$fedited by Martial Ruat 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (213 p.) 225 1 $aTopics in Medicinal Chemistry,$x1862-2461 ;$v16 300 $aDescription based upon print version of record. 311 $a3-319-19754-1 320 $aIncludes bibliographical references and index. 327 $aCanonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure. 330 $aMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. 410 0$aTopics in Medicinal Chemistry,$x1862-2461 ;$v16 606 $aMedicinal chemistry 606 $aProteins  606 $aCancer research 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 615 0$aMedicinal chemistry. 615 0$aProteins . 615 0$aCancer research. 615 14$aMedicinal Chemistry. 615 24$aReceptors. 615 24$aCancer Research. 676 $a571.889 702 $aRuat$b Martial$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298609303321 996 $aSmoothened Receptor in Cancer and Regenerative Medicine$92779770 997 $aUNINA