LEADER 04835nam 22007935 450 001 9910298606303321 005 20200630233345.0 010 $a3-319-72002-3 024 7 $a10.1007/978-3-319-72002-9 035 $a(CKB)3840000000347722 035 $a(MiAaPQ)EBC5287492 035 $a(DE-He213)978-3-319-72002-9 035 $a(PPN)224640690 035 $a(EXLCZ)993840000000347722 100 $a20180209d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aAmorphous Drugs $eBenefits and Challenges /$fby Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (230 pages) $cillustrations (some color) 311 $a3-319-72001-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aWhy amorphous drugs? -- Order vs. disorder in the solid state -- Amorphous drug solubility and absorption enhancement -- Amorphous drug preparation methods -- Physical instability - a key problem of amorphous drugs -- Amorphous drug formulation. 330 $aThis book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products. . 606 $aMedicinal chemistry 606 $aPharmaceutical technology 606 $aPhase transitions (Statistical physics) 606 $aThermodynamics 606 $aCeramics 606 $aGlass 606 $aComposites (Materials) 606 $aComposite materials 606 $aBiomedical engineering 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 606 $aPhase Transitions and Multiphase Systems$3https://scigraph.springernature.com/ontologies/product-market-codes/P25099 606 $aThermodynamics$3https://scigraph.springernature.com/ontologies/product-market-codes/P21050 606 $aCeramics, Glass, Composites, Natural Materials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z18000 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 615 0$aMedicinal chemistry. 615 0$aPharmaceutical technology. 615 0$aPhase transitions (Statistical physics). 615 0$aThermodynamics. 615 0$aCeramics. 615 0$aGlass. 615 0$aComposites (Materials). 615 0$aComposite materials. 615 0$aBiomedical engineering. 615 14$aMedicinal Chemistry. 615 24$aPharmaceutical Sciences/Technology. 615 24$aPhase Transitions and Multiphase Systems. 615 24$aThermodynamics. 615 24$aCeramics, Glass, Composites, Natural Materials. 615 24$aBiomedical Engineering and Bioengineering. 676 $a615.19 700 $aRams-Baron$b Marzena$4aut$4http://id.loc.gov/vocabulary/relators/aut$01061410 702 $aJachowicz$b Renata$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBoldyreva$b Elena$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aZhou$b Deliang$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aJamroz$b Witold$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aPaluch$b Marian$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910298606303321 996 $aAmorphous Drugs$92518752 997 $aUNINA