LEADER 04799nam 22006375 450 001 9910298604503321 005 20220412232627.0 010 $a3-319-91788-9 024 7 $a10.1007/978-3-319-91788-7 035 $a(CKB)4100000004834480 035 $a(DE-He213)978-3-319-91788-7 035 $a(MiAaPQ)EBC5426667 035 $a(PPN)22949580X 035 $a(EXLCZ)994100000004834480 100 $a20180609d2018 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 12$aA time-release history of the opioid epidemic$b[electronic resource] /$fby J.N. Campbell, Steven M. Rooney 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (XVIII, 134 p. 40 illus., 17 illus. in color.) 225 1 $aHistory of Chemistry,$x2212-991X 311 $a3-319-91787-0 327 $aIntroduction: Chemical Heterotopias -- Part One: Alkaloid Heterotopias -- Part Two: Synthetic Opiate Heterotopias -- Epilogue: Opioid Heterotopias. 330 $aThis Brief takes the reader on a chemical journey by following the history for over two centuries of how an opiate became an opioid, thus spawning an empire and a series of crises. These imperfect resemblances of alkaloids are both natural and synthetic substances that, particularly in America, are continually part of a growing concern about overuse. This seemed an inviting prospect for those in pain, but as the ubiquitous media coverage continues to lay bare, the levels of abuse point to the fact that perhaps an epidemic is upon us, if not a culture war. Seeking answers to how and why this addiction crisis transpired over two hundred years of long development, this Brief examines the role that the chemistry laboratory played in turning patients into consumers. By utilizing a host of diverse sources, this Brief seeks to trace the design and the production of opioids and their antecedents over the past two centuries. From the isolation and development of the first alkaloids with morphine that relieved pain within the home and on the battlefield, to the widespread use of nostrums and the addiction crisis that ensued, to the dissemination of drugs by what became known as Big Pharma after the World Wars; and finally, to competition from home-made pharmaceuticals, the progenitor was always, in some form, a type of chemistry lab. At times, the laboratory pressed science to think deeply about society's maladies, such as curing disease and alleviating pain, in order to look for new opportunities in the name of progress. Despite the best intentions opioids have created a paradox of pain as they were manipulated by creating relief with synthetic precision and influencing a dystopian vision. Thus, influence came in many forms, from governments, from the medical community, and from the entrepreneurial aspirations of the general populace. For better, but mostly for worse, all played a role in changing forever the trajectory of what started with the isolation of a compound in Germany. Combining chemistry and history in a rousing new long-form narrative that even broadens the definition of a laboratory, the origins and future of this complicated topic are carefully examined. 410 0$aHistory of Chemistry,$x2212-991X 606 $aChemistry?History 606 $aOrganic chemistry 606 $aMedicine?History 606 $aPharmacology 606 $aPsychopharmacology 606 $aHistory of Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C34000 606 $aOrganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19007 606 $aHistory of Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H64000 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aPsychopharmacology$3https://scigraph.springernature.com/ontologies/product-market-codes/H53010 615 0$aChemistry?History. 615 0$aOrganic chemistry. 615 0$aMedicine?History. 615 0$aPharmacology. 615 0$aPsychopharmacology. 615 14$aHistory of Chemistry. 615 24$aOrganic Chemistry. 615 24$aHistory of Medicine. 615 24$aPharmacology/Toxicology. 615 24$aPsychopharmacology. 676 $a540.9 700 $aCampbell$b J.N$4aut$4http://id.loc.gov/vocabulary/relators/aut$01057918 702 $aRooney$b Steven M$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910298604503321 996 $aA Time-Release History of the Opioid Epidemic$92495563 997 $aUNINA